The invention concerns a method for operation of a drive unit of a vehicle, including a drive machine and a transmission with at least two gears. A quantity that characterizes acceleration of the vehicle and a quantity that characterizes the power of the drive engine are continuously determined. A gear shift speed range and a second speed range bounded by a lowest and highest attainable speed in the target gear can be established for a gear shift process in the initial gear. The gear shift speed range is bounded at least by a lower gear shift speed and an upper gear shift speed and the second speed range is bounded by a lower target speed, as well as an additional speed. The gear shift process is initiated as a function of the determined acceleration. The lower target speed is achieved in a gear shift process in a first limiting stage (high acceleration at low input speeds or limited deceleration at low input speeds) during initiation of a gear shift at a number of gear shift speeds. The gear shift process between the first limiting state and the highest attainable speed in the target gear is initiated as a function of the determined quantities in the gear shift speed range in the initial gear.