发明授权
- 专利标题: Cephalosporin derivatives
- 专利标题(中): 头孢菌素衍生物
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申请号: US761738申请日: 1996-12-05
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公开(公告)号: US5734047A公开(公告)日: 1998-03-31
- 发明人: Choung U. Kim , Muzammil M. Mansuri , Peter F. Misco , John A. Wichtowski
- 申请人: Choung U. Kim , Muzammil M. Mansuri , Peter F. Misco , John A. Wichtowski
- 申请人地址: NJ Princeton
- 专利权人: Bristol-Myers Squibb Company
- 当前专利权人: Bristol-Myers Squibb Company
- 当前专利权人地址: NJ Princeton
- 主分类号: C07D501/00
- IPC分类号: C07D501/00 ; C07D501/36 ; A61K31/545
摘要:
Novel cephem derivatives represented by the general formula ##STR1## wherein Ar is an optionally substituted lipophilic phenyl, naphthyl, benzthiazolyl or pyridyl group; R.sup.1 represents a group of the formula ##STR2## in which R.sup.8 and R.sup.9 are each independently hydrogen, C.sub.1 -C.sub.6 alkyl or (C.sub.1 -C.sub.6)alkoxycarbonyl, said C.sub.1 -C.sub.6 alkyl group being optionally substituted by 1-5 hydroxy or C.sub.1 -C.sub.6 alkoxy groups; m is either 0 or 1; A is a C.sub.2 -C.sub.10 alkyl group optionally substituted by 1-5 hydroxy groups; and R.sup.2 and R.sup.3 are each independently hydrogen or C.sub.1 -C.sub.6 alkyl. The derivatives are gram-positive antibacterial agents especially useful in the treatment of diseases caused by methicillin-resistant Staphylococcus aureus.
公开/授权文献
- US4153942A Industrial control processor 公开/授权日:1979-05-08
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