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23 条记录 (耗时 0.016 秒)

    Phosphonomethoxy carbocyclic nucleosides and nucleotides
    1.
    发明授权
    Phosphonomethoxy carbocyclic nucleosides and nucleotides 失效
    膦基甲氧基碳环核苷酸和核苷酸

    公开(公告)号：US5744600A

    公开(公告)日：1998-04-28

    申请号：US357561

    申请日：1994-12-16

    申请人： Muzammil M. Mansuri ,  John C. Martin ,  Thomas W. Hudyma ,  Joanne J. Bronson ,  Louis M. Ferrara

    发明人： Muzammil M. Mansuri ,  John C. Martin ,  Thomas W. Hudyma ,  Joanne J. Bronson ,  Louis M. Ferrara

    IPC分类号： C07F9/6512 ,  A61K31/675 ,  C07F9/6561 ,  C07D473/18 ,  C07D473/34

    CPC分类号： C07F9/65121

    摘要： A compound of the Formula I or Formula II ##STR1## wherein R.sup.1 and R.sup.2 are independently hydrogen, hydroxy, chlorine, fluorine, bromine, or an organic substituent having 1 to 5 carbon atoms and selected from acyloxy having a hydrocarbon stem of 1 to 4 carbon atoms, alkoxy, alkylthio, amino, alkylamino and dialkylamino; R.sup.3 and R.sup.4 are independently hydrogen, or organic phosphonic ester substituents having 1 to 12 carbon atoms and selected from alkyl, alkenyl, aryl, and aralkyl; and B is a heterocyclic group selected from the group consisting of pyrimidine, purine, triazine, deazapurine, and triazole, attached through a ring nitrogen atom thereof optionally substituted with 1 to 3 substituents selected from the group consisting of hydroxy, mercapto, amino, hydrazino, fluoro, chloro, bromo, iodo, C.sub.1 to C.sub.3 alkyl, C2-C3 alkenyl, C2-C3 haloalkenyl, C1-C3 alkoxy, and C1-C3 alkylthio; and the pharmaceutically acceptable acid addition, metal, and amine salts thereof. The compositions of the invention are useful for, among other things, antiviral agents.

    摘要翻译： 式I或式II的化合物其中R 1和R 2独立地是氢，羟基，氯，氟，溴或具有1至5个碳原子并且选自具有烃的酰氧基的有机取代基 1至4个碳原子的烷氧基，烷硫基，氨基，烷基氨基和二烷基氨基; R3和R4独立地是氢，或具有1至12个碳原子并且选自烷基，烯基，芳基和芳烷基的有机膦酸酯取代基; 并且B是选自嘧啶，嘌呤，三嗪，脱氮嘌呤和三唑的杂环基，其通过环氮原子连接，任选被1-3个选自羟基，巯基，氨基，肼基的取代基取代 ，氟，氯，溴，碘，C 1至C 3烷基，C 2 -C 3烯基，C 2 -C 3卤代烯基，C 1 -C 3烷氧基和C 1 -C 3烷硫基; 及其药学上可接受的酸加成盐，金属盐和胺盐。 本发明的组合物尤其可用于抗病毒剂。

    Inhibitors of cyclin dependent kinases
    5.
    发明授权
    Inhibitors of cyclin dependent kinases 失效
    细胞周期蛋白依赖性激酶抑制剂

    公开(公告)号：US5733920A

    公开(公告)日：1998-03-31

    申请号：US551031

    申请日：1995-10-31

    申请人： Muzammil M. Mansuri ,  Krishna K. Murthi ,  Kollol Pal

    发明人： Muzammil M. Mansuri ,  Krishna K. Murthi ,  Kollol Pal

    IPC分类号： C07D311/30 ,  C07D405/04 ,  C07D405/14 ,  A61K31/44 ,  C07D405/02

    CPC分类号： C07D405/04 ,  C07D311/30 ,  C07D405/14

    摘要： The invention provides novel inhibitors of cyclin-dependent kinases, in particular inhibitors of the CDK/cyclin complexes such as CDK4/cyclin D1. The novel compounds are analogs of chromones. These compounds can be used for inhibiting excessive or abnormal cell proliferation. Thus, the novel compounds are useful for treating a subject with a disorder associated with excessive cell proliferation, such as cancer.

    摘要翻译： 本发明提供细胞周期蛋白依赖性激酶的新型抑制剂，特别是CDK /细胞周期蛋白复合物例如CDK4 /细胞周期蛋白D1的抑制剂。 新化合物是色酮的类似物。 这些化合物可用于抑制细胞增殖过多或异常。 因此，新化合物可用于治疗与过度细胞增殖相关的疾病如癌症的受试者。