发明授权
- 专利标题: Ifosfamide lyophilizate preparations
- 专利标题(中): 异环磷酰胺冻干制剂
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申请号: US752069申请日: 1996-11-19
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公开(公告)号: US5750131A公开(公告)日: 1998-05-12
- 发明人: Burkhard Wichert , Dieter Sauerbier , Jurgen Rawert
- 申请人: Burkhard Wichert , Dieter Sauerbier , Jurgen Rawert
- 申请人地址: DEX Dresden
- 专利权人: Asta Medica Aktiengesellschaft
- 当前专利权人: Asta Medica Aktiengesellschaft
- 当前专利权人地址: DEX Dresden
- 主分类号: A61K9/19
- IPC分类号: A61K9/19 ; A61K31/675 ; A61K47/10 ; A61K47/18 ; A61K47/36 ; A61K47/38 ; A61K9/00 ; A61K31/715
摘要:
The invention relates to improved ifosfamide preparations which are distinguished in that as primary auxiliary a polysaccharide, in general a glycan, preferably dextran, starches or cellulose, in particular dextrans having an MW of 20,000 to 85,000, modified starches such as hydroxyethyl starch and chemically modified celluloses such as hydroxyethylcellulose and sodium carboxymethylcellulose, a glycol ether, preferably polyethylene glycol, in particular polyethylene glycols having a molecular weight of 600 to 6000 or an amino acid, preferably alanine, leucine or glutamic acid, is added to them. The improved ifosfamide preparation can also contain as an auxiliary a pharmaceutically customary buffer, for example acetate, citrate or tris buffer, preferably phosphate buffer. In addition, improved ifosfamide preparations are obtained by addition of NaHCO.sub.3. The ifosfamide preparations according to the invention can comprise one or a combination of several auxiliaries. Mesna can be added to the formulation as a uroprotector.
公开/授权文献
- US4660765A Water sprinkler 公开/授权日:1987-04-28