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公开(公告)号：US20050124546A1
公开(公告)日：2005-06-09
申请号：US11039997
申请日：2005-01-24
CPC分类号： A61K9/0019 , A61K9/19 , A61K38/09 , A61K47/26 , Y10S514/80 , Y10S930/11 , Y10S930/13
摘要： A novel lyophilizate and method of preparation as well as the use of the lyophilizate to treat female infertility and for gonad protection. Cetrorelix is dissolved in acetic acid 30% v/v, the solution is transferred to water and freeze dried.
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公开(公告)号：US06828415B2
公开(公告)日：2004-12-07
申请号：US08468145
申请日：1995-06-06
IPC分类号： A61K3800
CPC分类号： A61K9/0019 , A61K9/19 , A61K38/09 , A61K47/26 , Y10S514/80 , Y10S930/11 , Y10S930/13
摘要： A novel lyophilizate and method of preparation as well as the use of the lyophilizate to treat female infertility and for gonad protection. Cetrorelix is dissolved in acetic acid 30% v/v, the solution is transferred to water and freeze dried.
摘要翻译： 一种新型的冷冻干燥剂和制备方法以及使用冻干剂治疗女性不育症和性腺保护。 将西曲瑞克溶于30％v / v的乙酸中，将溶液转移至水中并冷冻干燥。
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公开(公告)号：US5834520A
公开(公告)日：1998-11-10
申请号：US915586
申请日：1997-08-21
IPC分类号： A61K31/185 , A61K31/095
CPC分类号： A61K31/185
摘要： Injectable mesna solutions having a pH value higher than 7.5. The solutions have increased storage stability.
摘要翻译： 可注射的mesna溶液，其pH值高于7.5。 解决方案提高了储存稳定性。
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公开(公告)号：US5232919A
公开(公告)日：1993-08-03
申请号：US598742
申请日：1990-10-15
IPC分类号： C07D403/04
CPC分类号： C07D403/04 , Y10S514/826
摘要： An embonic acid salt of azelastine is disclosed which does not possess the bitter taste of azelastine, and which therefore is suitable for orally administered formulations.
摘要翻译： 公开了氮卓斯汀的乌头酸盐，其不具有氮卓斯汀的苦味，因此适用于口服制剂。
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公开(公告)号：US4959215A
公开(公告)日：1990-09-25
申请号：US325883
申请日：1989-03-20
申请人： Dieter Sauerbier , Otto Isaac , Wolfgang P. Brade
发明人： Dieter Sauerbier , Otto Isaac , Wolfgang P. Brade
IPC分类号： A61K9/00 , A61K9/19 , A61K31/675 , A61K47/26 , A61P35/00 , C07C323/66 , C07F9/6584
CPC分类号： A61K31/675 , A61K47/26 , A61K9/0019 , A61K9/19
摘要： An ifosfamide-mesna lyophilizate consists substantially of ifosfamide, 0.1-1.0 parts by weight of mesna and 0.1 to 17 parts by weight of hexitol. The product is obtained by freeze drying an aqueous or aqueous-ethanolic solution of ifosfamide and mesna.
摘要翻译： 异环磷酰胺 - 美沙仁冻干物质基本上由异环磷酰胺，0.1-1.0重量份的美司钠和0.1至17重量份己糖醇组成。 产物通过冷冻干燥异环磷酰胺和甲磺酸的水溶液或乙醇水溶液而获得。
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6.发明授权
公开(公告)号：US5446033A
公开(公告)日：1995-08-29
申请号：US137964
申请日：1993-10-19
IPC分类号： A61K31/685 , A61K9/00 , A61K31/09 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/24 , A61P35/00
CPC分类号： A61K31/685 , A61K47/02 , A61K47/10 , A61K47/12 , A61K9/0014
摘要： Solutions of alkylphosphocholines in glycerol alkyl ethers having enhanced storage stability containing a buffer which maintains the pH value to a range between 4 and 6.
摘要翻译： 烷基磷酰胆碱在甘油烷基醚中的溶液，其具有增强的储存稳定性，其含有将pH值保持在4和6之间的缓冲液。
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公开(公告)号：US5252341A
公开(公告)日：1993-10-12
申请号：US930783
申请日：1992-08-17
申请人： Dieter Sauerbier , Jurgen Engel , Eckhard Milsmann
发明人： Dieter Sauerbier , Jurgen Engel , Eckhard Milsmann
CPC分类号： A61K9/0095 , A61K31/185 , A61K9/0007 , A61K9/2077 , A61K9/5026
摘要： A granulate containing mesna is made by granulating mesna in the presence of an alcohol, acetone or a mixture of one of these with water. The granulate may be converted to tablets, along with other agents. The tablets contain0.01-1 parts by weight of a binding agent0.03-0.4 parts by weight of a disintegrant0.01-0.2 parts by weight of a lubricant and0.1-1 parts by weight of a filling agent as well as, in the case of an effervescent tablet, an additional 0.05-30 parts by weight of a conventional physiologically acceptable effervescent mixture.
摘要翻译： 含有mesna的颗粒是通过在醇，丙酮或其中之一与水的混合物存在下制粒美司钠制成的。 颗粒可以与其他药剂一起转化成片剂。 片剂含有0.01-1重量份的粘合剂0.03-0.4重量份的崩解剂0.01-0.2重量份的润滑剂和0.1-1重量份的填充剂，以及在 泡腾片剂，另外0.05-30重量份的常规生理上可接受的泡腾混合物。
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公开(公告)号：US07605121B2
公开(公告)日：2009-10-20
申请号：US11039997
申请日：2005-01-24
申请人： Jürgen Engel , Burkhard Wichert , Dieter Sauerbier , Gudrun Sauerbier, legal representative , Thomas Reissmann
CPC分类号： A61K9/0019 , A61K9/19 , A61K38/09 , A61K47/26 , Y10S514/80 , Y10S930/11 , Y10S930/13
摘要： A novel lyophilizate and method of preparation as well as the use of the lyophilizate to treat female infertility and for gonad protection. Cetrorelix is dissolved in acetic acid 30% v/v, the solution is transferred to water and freeze dried.
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公开(公告)号：US06863891B2
公开(公告)日：2005-03-08
申请号：US10040457
申请日：2002-01-09
CPC分类号： A61K9/0019 , A61K9/19 , A61K38/09 , A61K47/26 , Y10S514/80 , Y10S930/11 , Y10S930/13
摘要： A novel lyophilizate and method of preparation as well as the use of the lyophilizate to treat female infertility and for gonad protection. Cetrorelix is dissolved in acetic acid 30% v/v, the solution is transferred to water and freeze dried.
摘要翻译： 一种新型的冷冻干燥剂和制备方法以及使用冻干剂治疗女性不育症和性腺保护。 将西曲瑞克溶于30％v / v的乙酸中，将溶液转移至水中并冷冻干燥。
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公开(公告)号：US5262169A
公开(公告)日：1993-11-16
申请号：US730178
申请日：1991-07-16
申请人： Dieter Sauerbier , Jurgen Engel , Eckhard Milsmann
发明人： Dieter Sauerbier , Jurgen Engel , Eckhard Milsmann
IPC分类号： A61K9/16 , A61K9/00 , A61K9/20 , A61K9/28 , A61K9/46 , A61K9/50 , A61K31/095 , A61K31/185 , A61P1/00 , A61P39/02
CPC分类号： A61K9/0007 , A61K31/185 , A61K9/0095 , A61K9/2077 , A61K9/5026
摘要： A granulate containing mesna is made by granulating mesna in the presence of an alcohol, acetone or a mixture of one of these with water. The granulate may be converted to tablets, along with other agents. The tablets contain:0.01-1 parts by weight of a binding agent0.03-0.4 parts by weight of a disintegrant0.01-0.2 parts by weight of a lubricant and0.1-1 parts by weight of a filling agent as well as, in the case of an effervescent tablet, an additional 0.05-30 parts by weight of a conventional physiologically acceptable effervescent mixture.
摘要翻译： 含有mesna的颗粒是通过在醇，丙酮或其中之一与水的混合物存在下制粒美司钠制成的。 颗粒可以与其他药剂一起转化成片剂。 片剂含有：0.01-1重量份的粘合剂，0.03-0.4重量份的崩解剂0.01-0.2重量份的润滑剂和0.1-1重量份的填充剂，在这种情况下 的泡腾片剂，另外0.05-30重量份的常规生理上可接受的泡腾混合物。
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