发明授权
- 专利标题： Method for preparation of amino acid thiohydantoins
- 专利标题（中）： 制备氨基酸硫代乙内酰脲的方法
-
申请号： US307687申请日： 1994-09-23
-
公开(公告)号： US5756667A公开(公告)日： 1998-05-26
- 发明人: Adam Inglis , Albert Peng Sheng Tseng , Peter Laurence Adams
- 申请人： Adam Inglis , Albert Peng Sheng Tseng , Peter Laurence Adams
- 申请人地址： AUX Darlinghurst
- 专利权人： Garvan Institute of Medical Research
- 当前专利权人： Garvan Institute of Medical Research
- 当前专利权人地址： AUX Darlinghurst
- 优先权： AUXPL1520 19920325; AUXPL4798 19920917
- 主分类号： C07D233/72
- IPC分类号： C07D233/72 ; C07D233/86 ; C07D487/04 ; C07K1/12 ; G01N33/68 ; C07K1/107
摘要：
The present invention consists in a method of preparing amino thiohydantoins either in isolation or as the C-terminals residue of a peptide. The method comprises reacting the amino acid or peptide with an acylating agent and thiocyanate or isothiocyanates in the presence of a strong acid. The present invention also relates to an improved method for C-terminal sequencing of peptides which routinely analyses all of the common amino acids of peptides. The invention involves the use of a strong, volatile, anhydrous organic or mineral acid to cleave the terminal amino acid thiohydantoin.
公开/授权文献
- US4906426A Process for producing an alumina-silica-chromia ternary fiber 公开/授权日：1990-03-06
信息查询
