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公开(公告)号：US5656602A
公开(公告)日：1997-08-12
申请号：US170360
申请日：1994-03-03
摘要： The present invention provides peptides and compounds which inhibit the enzyme activity of Type II phospholipases A.sub.2. The preferred compounds are pentapeptides. Where the phospholipase is human Type II phospholipase A.sub.2 the preferred peptides are FLSYK and KFLSY.
摘要翻译： PCT No.PCT / AU92 / 00333 Sec。 371日期1994年3月3日 102（e）1994年3月3日PCT PCT 1992年7月6日PCT公布。 出版物WO93 / 01215 PCT 日期1993年1月21日本发明提供抑制II型磷脂酶A2的酶活性的肽和化合物。 优选的化合物是五肽。 当磷脂酶是人类II型磷脂酶A2时，优选的肽是FLSYK和KFLSY。
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2.发明授权Non-steroidal glucocorticoid inhibitors and their use in treating inflammation, allergy and auto-immune conditions 有权非类固醇糖皮质激素抑制剂及其在治疗炎症，过敏和自身免疫条件方面的应用公开(公告)号：US08247377B2
公开(公告)日：2012-08-21
申请号：US12303791
申请日：2007-06-11
申请人： Heather Anne Barnett , Ian Baxter Campbell , Diane Mary Coe , Anthony William James Cooper , Graham George Adam Inglis , Haydn Terence Jones , Steven Philip Keeling , Simon John Fawcett MacDonald , Iain McFarlane McLay , Philip Alan Skone , Gordon Gad Weingarten , James Michael Woolven
发明人： Heather Anne Barnett , Ian Baxter Campbell , Diane Mary Coe , Anthony William James Cooper , Graham George Adam Inglis , Haydn Terence Jones , Steven Philip Keeling , Simon John Fawcett MacDonald , Iain McFarlane McLay , Philip Alan Skone , Gordon Gad Weingarten , James Michael Woolven
CPC分类号： C07D231/38
摘要： The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or autoimmune conditions.
摘要翻译： 本发明提供式（I）化合物：其制备方法，包含所述化合物的药物组合物和所述组合物的制备，中间体和用于制备用于治疗性治疗的药物的用途，特别是 治疗炎症，过敏和/或自身免疫病症。
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公开(公告)号：US20090074675A1
公开(公告)日：2009-03-19
申请号：US11910935
申请日：2006-04-12
申请人： Colin David Eldred , David House , Graham George Adam Inglis , Simon John Fawcett MacDonald , Philip Alan Skone
发明人： Colin David Eldred , David House , Graham George Adam Inglis , Simon John Fawcett MacDonald , Philip Alan Skone
IPC分类号： A61K9/12 , C07D401/04 , A61K31/4439
CPC分类号： C07D405/14 , C07D231/56 , C07D401/04 , C07D405/12
摘要： A compound of formula (I): wherein A1 represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl; X represents —C(R3)— or nitrogen; when X represents —C(R3)—, R2 represents hydrogen and R1 represents fluorine, R3 represents hydrogen or fluorine, when X represents —C(R3)— and R2 and R1 each represent hydrogen, R3 represents hydrogen, hydroxy, methoxy or fluorine, when X represents —C(R3)— and R2 represents hydroxy, methoxy, —CO2CH3 or —CO2CH2CH3, R1 and R3 each represent hydrogen, when X represents nitrogen, R1 and R2 each represent hydrogen; and Y represents H or methyl; or a physiologically functional derivative thereof.
摘要翻译： 式（I）的化合物：其中A1表示2,3-二氢-1-苯并呋喃-7-基，5-氟-2-甲氧基 - 苯基或5-氟-2-羟基 - 苯基; X表示-C（R 3） - 或氮; 当X表示-C（R3） - 时，R2表示氢，R1表示氟，R3表示氢或氟，当X表示-C（R3） - 且R2和R1各自表示氢时，R3表示氢，羟基，甲氧基或氟 当X表示-C（R 3） - 且R 2表示羟基，甲氧基，-CO 2 CH 3或-CO 2 CH 2 CH 3时，R 1和R 3各自表示氢，当X表示氮时，R 1和R 2各自表示氢; Y表示H或甲基; 或其生理功能衍生物。
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公开(公告)号：US08093281B2
公开(公告)日：2012-01-10
申请号：US11910935
申请日：2006-04-12
申请人： Colin David Eldred , David House , Graham George Adam Inglis , Simon John Fawcett MacDonald , Philip Alan Skone
发明人： Colin David Eldred , David House , Graham George Adam Inglis , Simon John Fawcett MacDonald , Philip Alan Skone
IPC分类号： A61K31/416 , C07D231/56
CPC分类号： C07D405/14 , C07D231/56 , C07D401/04 , C07D405/12
摘要： A compound of formula (I): wherein A1 represents 2,3-dihydro-1-benzofuran-7-yl, 5-fluoro-2-methoxy-phenyl or 5-fluoro-2-hydroxy-phenyl; X represents —C(R3)— or nitrogen; when X represents —C(R3)—, R2 represents hydrogen and R1 represents fluorine, R3 represents hydrogen or fluorine, when X represents —C(R3)— and R2 and R1 each represent hydrogen, R3 represents hydrogen, hydroxy, methoxy or fluorine, when X represents —C(R3)— and R2 represents hydroxy, methoxy, —CO2CH3 or —CO2CH2CH3, R1 and R3 each represent hydrogen, when X represents nitrogen, R1 and R2 each represent hydrogen; and Y represents H or methyl; or a physiologically functional derivative thereof.
摘要翻译： 式（I）的化合物：其中A1表示2,3-二氢-1-苯并呋喃-7-基，5-氟-2-甲氧基 - 苯基或5-氟-2-羟基 - 苯基; X表示-C（R 3） - 或氮; 当X表示-C（R3） - 时，R2表示氢，R1表示氟，R3表示氢或氟，当X表示-C（R3） - 且R2和R1各自表示氢时，R3表示氢，羟基，甲氧基或氟 当X表示-C（R 3） - 且R 2表示羟基，甲氧基，-CO 2 CH 3或-CO 2 CH 2 CH 3时，R 1和R 3各自表示氢，当X表示氮时，R 1和R 2各自表示氢; Y表示H或甲基; 或其生理功能衍生物。
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公开(公告)号：US06177425B1
公开(公告)日：2001-01-23
申请号：US09508314
申请日：2000-05-05
申请人： Michael Dennis Dowle , Harry Finch , Lee Andrew Harrison , Graham George Adam Inglis , Martin Redpath Johnson , Simon John Fawcett MacDonald , Pritom Shah
发明人： Michael Dennis Dowle , Harry Finch , Lee Andrew Harrison , Graham George Adam Inglis , Martin Redpath Johnson , Simon John Fawcett MacDonald , Pritom Shah
IPC分类号： A61K31407
CPC分类号： C07D487/04
摘要： According to the invention there are provided Hexahydro-Pyrrolo[3,4-b]pyrrol-2-one compounds of formula (1), (relative stereochemistry indicated), wherein R1, R2 and R3 are as defined in the specification. Compounds of formula (1) are useful inter alia in the treatment or chronic bronchitis.
摘要翻译： 根据本发明，提供式（1）的六氢 - 吡咯并[3,4-b]吡咯-2-酮化合物（所示的相对立体化学），其中R1，R2和R3如说明书中所定义。 式（1）的化合物尤其可用于治疗或慢性支气管炎。
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6.发明申请Non-Steroidal Glucocorticoid Inhibitors and Their Use in Treating Inflammation, Allergy and Auto-Immune Conditions 审中-公开非甾类糖皮质激素抑制剂及其在治疗炎症，过敏和自身免疫病症中的应用公开(公告)号：US20120277279A1
公开(公告)日：2012-11-01
申请号：US13548573
申请日：2012-07-13
申请人： Heather Anne BARNETT , Ian Baxter Campbell , Diane Mary Coe , Anthony William James Cooper , Graham George Adam Inglis , Haydn Terence Jones , Steven Philip Keeling , Simon John Fawcett MacDonald , Iain McFarlane McLay , Philip Alan Skone , Gordon Gad Weingarten , James Michael Woolven
发明人： Heather Anne BARNETT , Ian Baxter Campbell , Diane Mary Coe , Anthony William James Cooper , Graham George Adam Inglis , Haydn Terence Jones , Steven Philip Keeling , Simon John Fawcett MacDonald , Iain McFarlane McLay , Philip Alan Skone , Gordon Gad Weingarten , James Michael Woolven
IPC分类号： A61K31/415 , A61P37/08 , A61P11/10 , A61P25/00 , A61P29/00 , A61P17/00 , A61P25/28 , A61P35/00 , A61P31/06 , A61P37/06 , A61P17/06 , A61P17/04 , A61P11/06 , A61P19/04
CPC分类号： C07D231/38
摘要： The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or auto-immune conditions.
摘要翻译： 本发明提供式（I）化合物：其制备方法，包含所述化合物的药物组合物和所述组合物的制备，中间体和用于制备用于治疗性治疗的药物的用途，特别是 治疗炎症，过敏和/或自身免疫状况。
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公开(公告)号：US20100234441A1
公开(公告)日：2010-09-16
申请号：US12303791
申请日：2007-06-11
申请人： Heather Anne Barnett , Ian Baxter Campbell , Diane Mary Coe , Anthony William James Cooper , Graham George Adam Inglis , Haydn Terence Jones , Steven Philip Keeling , Simon John Fawcett MacDonald , Iain McFarlane McLay , Philip Alan Skone , Gordon Gad Weingarten , James Michael Woolven
发明人： Heather Anne Barnett , Ian Baxter Campbell , Diane Mary Coe , Anthony William James Cooper , Graham George Adam Inglis , Haydn Terence Jones , Steven Philip Keeling , Simon John Fawcett MacDonald , Iain McFarlane McLay , Philip Alan Skone , Gordon Gad Weingarten , James Michael Woolven
IPC分类号： A61K31/415 , C07D231/38 , A61P19/02 , A61P17/00 , A61P29/00 , A61P25/00
CPC分类号： C07D231/38
摘要： The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation, allergy and/or autoimmune conditions.
摘要翻译： 本发明提供式（I）化合物：其制备方法，包含所述化合物的药物组合物和所述组合物的制备，中间体和用于制备用于治疗性治疗的药物的用途，特别是 治疗炎症，过敏和/或自身免疫病症。
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8.发明申请公开(公告)号：US20100035926A1
公开(公告)日：2010-02-11
申请号：US12518308
申请日：2007-12-19
申请人： Ian Baxter Campbell , Diane Mary Coe , Anthony William James Cooper , Graham George Adam Inglis , Haydn Terence Jones , Steven Philip Keeling , Simon John Fawcett MacDonald , Philip Alan Skone , Gordon Gad Weingarten
发明人： Ian Baxter Campbell , Diane Mary Coe , Anthony William James Cooper , Graham George Adam Inglis , Haydn Terence Jones , Steven Philip Keeling , Simon John Fawcett MacDonald , Philip Alan Skone , Gordon Gad Weingarten
IPC分类号： A61K31/415 , A61K31/4439 , A61K31/4709 , A61P29/00 , A61P37/00 , C07D231/38 , C07D401/12
CPC分类号： C07D231/38 , C07C233/78 , C07D303/36 , C07D401/12
摘要： The present invention provides compounds of formula (I): a process for their preparation, to pharmaceutical compositions comprising the compounds and the preparation of said compositions, to intermediates, and to use of the compounds for the manufacture of a medicament for therapeutic treatment, particularly for the treatment of inflammation.
摘要翻译： 本发明提供式（I）化合物：其制备方法，包含所述化合物的药物组合物和所述组合物的制备，中间体和用途，用于制备用于治疗性治疗的药物，特别是 用于治疗炎症。
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公开(公告)号：US07288564B2
公开(公告)日：2007-10-30
申请号：US10450894
申请日：2001-12-20
申请人： Derek Anthony Demaine , Gerard Martin Paul Giblin , Rachel Elizabeth Hosking , Graham George Adam Inglis , Xiao Qing Lewell , Simon John Fawcett MacDonald , Andrew McMurtrie Mason , Martin Edward Swarbrick
发明人： Derek Anthony Demaine , Gerard Martin Paul Giblin , Rachel Elizabeth Hosking , Graham George Adam Inglis , Xiao Qing Lewell , Simon John Fawcett MacDonald , Andrew McMurtrie Mason , Martin Edward Swarbrick
IPC分类号： A61K31/404 , C07D209/04
CPC分类号： C07D407/04 , C07D209/18 , C07D409/04
摘要： Compounds of formula (I) or salts or solvates thereof or physiologically functional derivatives thereof are potent binders at the EP4 receptor and are of use in the treatment or prevention of conditions such as a pain, inflammatory, immunological, bone, neurodegenerative or renal disorder.
摘要翻译： 式（I）化合物或其盐或溶剂合物或其生理功能衍生物是EP4受体的有效结合剂，并且可用于治疗或预防诸如疼痛，炎症，免疫学，骨骼，神经变性或肾脏疾病的病症。
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公开(公告)号：US07230114B2
公开(公告)日：2007-06-12
申请号：US10488791
申请日：2002-08-30
申请人： Brian David Judkins , Simon John Fawcett MacDonald , Derek Anthony Demaine , Graham George Adam Inglis , Julie Nicole Hamblin
发明人： Brian David Judkins , Simon John Fawcett MacDonald , Derek Anthony Demaine , Graham George Adam Inglis , Julie Nicole Hamblin
IPC分类号： C07D233/00
CPC分类号： C07D407/06 , C07D309/28 , Y02P20/55
摘要： Compounds of formula (I), methods for their preparation and their use in the manufacture of neuraminidase inhibitor conjugates. Wherein R represents as carboxylic acid protecting group; P1 and P2 can be the same or different and are selected from amine protecting groups; P3 represents a protecting group for 1, 2 diols; and LG represents a leaving group
摘要翻译： 式（I）的化合物，其制备方法及其在制备神经氨酸酶抑制剂缀合物中的用途。 其中R表示羧酸保护基; P 1和P 2可以相同或不同，并且选自胺保护基; P 3表示1,2二醇的保护基; LG代表离职团体
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