Invention Grant
US5756809A Process for the preparation of
(2RS,3RS)-3-(2'-aminophenylthio)-2-hydroxy-3-(4"-methoxyphenyl)-propioni
c acid methyl ester
失效
制备（2RS，3RS）-3-（2'-氨基苯硫基）-2-羟基-3-（4“ - 甲氧基苯基） - 丙酸甲酯的方法
- Patent Title: Process for the preparation of (2RS,3RS)-3-(2'-aminophenylthio)-2-hydroxy-3-(4"-methoxyphenyl)-propioni c acid methyl ester
- Patent Title (中): 制备（2RS，3RS）-3-（2'-氨基苯硫基）-2-羟基-3-（4“ - 甲氧基苯基） - 丙酸甲酯的方法
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Application No.: US742074Application Date: 1996-11-01
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Publication No.: US5756809APublication Date: 1998-05-26
- Inventor: Ferdinand Hagedorn , Helmut Fiege
- Applicant: Ferdinand Hagedorn , Helmut Fiege
- Applicant Address: DEX Leverkusen
- Assignee: Bayer Aktiengesellschaft
- Current Assignee: Bayer Aktiengesellschaft
- Current Assignee Address: DEX Leverkusen
- Priority: DEX19541717.8 19951109
- Main IPC: C07B53/00
- IPC: C07B53/00 ; C07C319/14 ; C07C319/18 ; C07C323/56 ; C07C149/40
Abstract:
(2RS,3RS)-3-(2'-aminophenylthio)-2-hydroxy-3-(4"-methoxyphenyl)-propionic acid methyl ester, an important precursor for the preparation of the pharmaceutical active substance diltiazem, is obtained in a particularly high stereoselectivity and yield by addition of o-aminothiophenol onto 3-(4'-methoxyphenyl)-glycidic acid methyl ester if the reaction is carried out in the presence of alkali metal salts of weak acids in the presence of catalytic amounts of iron compounds.
Public/Granted literature
- US5128369A Arylalkylamine derivatives Public/Granted day:1992-07-07
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