发明授权
US5763235A 5-aminolevulinic acid producing microorganism and process for producing
5-aminolevulinic acid
失效
5-氨基乙酰丙酸生产微生物和生产5-氨基乙酰丙酸的方法
- 专利标题: 5-aminolevulinic acid producing microorganism and process for producing 5-aminolevulinic acid
- 专利标题(中): 5-氨基乙酰丙酸生产微生物和生产5-氨基乙酰丙酸的方法
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申请号: US813088申请日: 1997-03-07
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公开(公告)号: US5763235A公开(公告)日: 1998-06-09
- 发明人: Keitaro Watanabe , Seiji Nishikawa , Tohru Tanaka , Yasushi Hotta
- 申请人: Keitaro Watanabe , Seiji Nishikawa , Tohru Tanaka , Yasushi Hotta
- 申请人地址: JPX Tokyo JPX Tokyo
- 专利权人: Cosmo Research Institute,Cosmo Oil Co., Ltd.
- 当前专利权人: Cosmo Research Institute,Cosmo Oil Co., Ltd.
- 当前专利权人地址: JPX Tokyo JPX Tokyo
- 优先权: JPX6-316251 19941220; JPX6-336046 19941222
- 主分类号: C12P13/00
- IPC分类号: C12P13/00
摘要:
A microorganism that produces 5-aminolevulinic acid, wherein the microorganism has a 5-aminolevulinic acid dehydratase variant having a reduced inhibitor constant for a 5-aminolevulinic acid dehydratase inhibitor. A microorganism that produces 5-aminolevulinic acid, wherein the microorganism is a photosynthetic bacterium that produces 5-aminolevulinic acid without light irradiation. A process for producing 5-aminolevulinic acid comprising the step of culturing a microorganism that produces 5-aminolevulinic acid in a culture medium under at least one condition selected from the group consisting of (a) less than 1 ppm of dissolved oxygen concentration in the culture medium, (b) from -180 to 50 mV of oxidation-reduction potential in the culture medium, and (c from 5.times.10.sup.-9 to (KrM-2.times.10.sup.-8) (mol of O.sub.2 /ml.multidot.min.cndot.cell) of cellular respiration rate, wherein KrM represents the maximum cellular respiration rate when oxygen is supplied in an excess quantity.
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