公开(公告)号：US09295660B2

公开(公告)日：2016-03-29

申请号：US13883038

申请日：2011-11-09

Applicant: Masaaki Wachi ,  Shigeharu Sato ,  Tohru Tanaka ,  Kiwamu Takahashi

Inventor： Masaaki Wachi ,  Shigeharu Sato ,  Tohru Tanaka ,  Kiwamu Takahashi

IPC: A61K31/197 ,  A61K31/16 ,  A61K31/221 ,  A61K9/00 ,  A61K9/107 ,  A61K9/20

CPC classification number: A61K31/197 ,  A61K9/0019 ,  A61K9/107 ,  A61K9/2018 ,  A61K9/2027 ,  A61K31/16 ,  A61K31/221 ,  Y02A50/411

Abstract: Provided is a preventive and/or therapeutic agent for malaria, comprising, as an active ingredient, 5-acetamido-4-oxo-5-hexenoic acid (Alaremycin) or a derivative thereof. A preventive and/or therapeutic agent for malaria is used which comprises, as an active ingredient, Alaremycin or a derivative thereof represented by formula (I) (wherein R1 represents a hydroxy group, an amino group, or a substituted or unsubstituted straight chain or branched alkoxy group or alkylamino group having 1 to 8 carbons; R2 represents hydrogen, a substituted or unsubstituted straight chain or branched alkyl group having 1 to 8 carbons, or a substituted or unsubstituted aromatic group having 4 to 10 carbons; and R3 represents hydrogen or a methyl group).

Abstract translation: 本发明提供疟疾的预防和/或治疗剂，其包含作为活性成分的5-乙酰氨基-4-氧代-5-己烯酸（阿拉霉霉素）或其衍生物。 使用疟疾的预防和/或治疗剂，其包含作为活性成分的由式（I）表示的阿拉霉素或其衍生物（其中R 1表示羟基，氨基或取代或未取代的直链或 支链烷氧基或碳原子数为1〜8的烷基氨基; R2表示氢，取代或未取代的碳原子数1〜8的直链或支链烷基或取代或未取代的碳原子数4〜10的芳基，R3表示氢或 甲基）。

公开(公告)号：US09095165B2

公开(公告)日：2015-08-04

申请号：US13123374

申请日：2009-10-27

Applicant: Tohru Tanaka

Inventor： Tohru Tanaka

IPC: A61K31/198 ,  A61K31/295 ,  A61K33/26 ,  A23L1/305 ,  A23L1/30 ,  A23L1/304 ,  A61K31/197 ,  A61K31/555 ,  A61K45/06

CPC classification number: A61K31/197 ,  A23L33/10 ,  A23L33/16 ,  A23L33/165 ,  A23L33/175 ,  A61K31/198 ,  A61K31/295 ,  A61K31/555 ,  A61K33/26 ,  A61K45/06 ,  A61K2300/00

Abstract: It is to provide a pharmaceutical composition which is different from an existing therapeutic agent of an adult disease, of a biochemical reaction-inhibiting type, and which action mechanism is to improve the basal metabolism, wherein the composition has no side effects, and does not generate drug resistance against adult disease; and a method for preventing/treating an adult disease by using the same. It is to provide a composition for preventing/ameliorating an adult disease such as metabolic syndrome, diabetes, hyperlipidemia, hypertension, impaired liver function, renal failure, adiposity, erectile dysfunction, menopausal disorder, shoulder discomfort, and low back pain, comprising 5-aminolevulinic acid (ALA), its derivative, or salt thereof, preferably comprising ALA, its derivative, or salt thereof, and an iron compound such as sodium ferrous citrate, iron sodium citrate and iron ammonium citrate; a food or food material for preventing/ameliorating an adult disease comprising the composition; and a method for using the composition for preparing an agent for preventing/ameliorating an adult disease.

Abstract translation: 本发明提供与生物化学反应抑制型的成人疾病的现有治疗剂不同的药物组合物，其作用机理是改善基础代谢，其中该组合物没有副作用，不 产生抗成年病的药物; 以及通过使用它们预防/治疗成人疾病的方法。 本发明提供一种用于预防/改善诸如代谢综合征，糖尿病，高脂血症，高血压，肝功能障碍，肾衰竭，肥胖，勃起功能障碍，绝经障碍，肩部不适和腰痛的成人疾病的组合物， 氨基乙酰丙酸（ALA），其衍生物或其盐，优选包含ALA，其衍生物或其盐，以及铁化合物如柠檬酸亚铁铵，柠檬酸铁钠和柠檬酸铁铵; 用于预防/改善包含该组合物的成人疾病的食品或食品材料; 以及使用该组合物制备用于预防/改善成人疾病的药剂的方法。

公开(公告)号：US20140249217A1

公开(公告)日：2014-09-04

申请号：US14350488

申请日：2012-09-12

Applicant: Ko Rii ,  Kiwamu Takahashi ,  Naomi Haga ,  Fuminori Abe ,  Tohru Tanaka ,  Motowo Nakajima ,  Hidenori Ito

Inventor： Ko Rii ,  Kiwamu Takahashi ,  Naomi Haga ,  Fuminori Abe ,  Tohru Tanaka ,  Motowo Nakajima ,  Hidenori Ito

IPC: A61K31/197 ,  A61K31/295

CPC classification number: A61K31/197 ,  A01N1/0226 ,  A61K31/22 ,  A61K31/295 ,  A61K33/26 ,  A61K35/17 ,  A61K45/06 ,  A61K2035/122 ,  A61K2035/124 ,  A61K2300/00

Abstract: The present invention provides an agent for promoting graft survival which can suppress rejection without use of existing immunosuppressants, an organ preservation solution capable of maintaining the freshness of an organ excised from a donor, and the like. An agent for promoting graft survival or an organ preservation solution is prepared, which comprises 5-aminolevulinic acid (ALA) or a derivative thereof, or a salt of ALA or the derivative and an iron compound as active ingredients. Preferable examples of the ALAs can include ALA and various esters such as methyl ester, ethyl ester, propyl ester, butyl ester, and pentyl ester of ALA, and their hydrochlorides, phosphates, and sulfates. Preferable examples of the iron compound can include sodium ferrous citrate.

Abstract translation: 本发明提供了一种用于促进移植物存活的药剂，其可以抑制不使用现有的免疫抑制剂的排斥反应，能够保持从供体排出的器官的新鲜度的器官保存溶液等。 制备促进移植物存活的药物或器官保存溶液，其包含5-氨基乙酰丙酸（ALA）或其衍生物，或ALA或其衍生物和铁化合物的盐作为活性成分。 ALA的优选实例可以包括ALA和各种酯，例如ALA的甲酯，乙酯，丙酯，丁酯和戊酯，以及它们的盐酸盐，磷酸盐和硫酸盐。 铁化合物的优选实例可包括柠檬酸亚铁钠。

公开(公告)号：US08563605B2

公开(公告)日：2013-10-22

申请号：US12736782

申请日：2009-05-13

Applicant: Setsuko Miyanari ,  Masumi Takahashi ,  Masahiro Ishizuka ,  Tohru Tanaka

Inventor： Setsuko Miyanari ,  Masumi Takahashi ,  Masahiro Ishizuka ,  Tohru Tanaka

IPC: A01N55/02 ,  A61K31/295

CPC classification number: A61K31/197 ,  A23L33/10 ,  A23L33/16 ,  A61K33/26 ,  A61K2300/00

Abstract: The present invention is intended to provide an agent for treating male infertility which is highly effective to male infertility, and having few side effects. To achieve the object, an agent for treating male infertility comprising δ-amino levulinic acid shown by general formula (1), its derivative or salt thereof: R2R1NCH2COCH2CH2COR3  (1) [wherein R1 and R2 independently represent a hydrogen atom, alkyl group, acyl group, alkoxycarbonyl group, aryl group, or aralkyl group; R3 represents a hydroxy group, alkoxy group, acyloxy group, alkoxycarbonyloxy group, aryloxy group, aralkyloxy group or amino group] can be used.

Abstract translation: 本发明旨在提供一种治疗男性不育症的药剂，其对男性不育症具有高度有效性，并且副作用很少。 为了达到上述目的，本发明提供一种治疗男性不育症的药剂，其含有通式（1）所示的δ-氨基乙酰丙酸，其衍生物或其盐：R2R1NCH2COCH2CH2COR3（1）[其中R1和R2独立地表示氢原子，烷基，酰基 基团，烷氧基羰基，芳基或芳烷基; R3表示羟基，烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基]。

公开(公告)号：US08471061B2

公开(公告)日：2013-06-25

申请号：US13418465

申请日：2012-03-13

Applicant: Naohisa Tachiya ,  Seiji Nishikawa ,  Mai Higo ,  Tohru Tanaka ,  Masahiro Ishizuka ,  Hideki Okada

Inventor： Naohisa Tachiya ,  Seiji Nishikawa ,  Mai Higo ,  Tohru Tanaka ,  Masahiro Ishizuka ,  Hideki Okada

IPC: C07C227/40 ,  C07C227/42 ,  C07C227/16 ,  C07C229/22

CPC classification number: A01N37/44 ,  A61K41/0061 ,  A61K49/0021 ,  C07C227/00 ,  C07C229/22 ,  C07C309/30 ,  C07F9/11

Abstract: A 5-aminolevulinic acid salt which is useful in fields of microorganisms, fermentation, animals, medicaments, plants and the like; a process for producing the same; a medical composition comprising the same; and a plant activator composition comprising the same.

Abstract translation: 可用于微生物，发酵，动物，药物，植物等领域的5-氨基乙酰丙酸盐; 其制造方法; 包含其的医药组合物; 和包含其的植物活化剂组合物。

公开(公告)号：US20110244110A1

公开(公告)日：2011-10-06

申请号：US13156963

申请日：2011-06-09

Applicant: Tohru Tanaka ,  Satofumi Kawata

Inventor： Tohru Tanaka ,  Satofumi Kawata

IPC: C12C3/00

CPC classification number: A01N37/44

Abstract: A hop alpha acid or hop oil content enhancer, which contains 5-aminolevulinic acid, or a derivative thereof represented by the following formula (1), or a salt thereof as an active ingredient: R2R1NCH2COCH2CH2COR3  (1) wherein R1 and R2 each independently represents a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; R3 represents a hydroxyl group, an alkoxy group, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group.

Abstract translation: 包含由下式（1）表示的5-氨基乙酰丙酸或其衍生物或其盐作为活性成分的啤酒花α酸或啤酒花油含量增强剂：R2R1NCH2COCH2CH2COR3（1）其中R1和R2各自独立地表示 氢原子，烷基，酰基，烷氧基羰基，芳基或芳烷基; R3表示羟基，烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基。

公开(公告)号：US20110196033A1

公开(公告)日：2011-08-11

申请号：US13123374

申请日：2009-10-27

Applicant: Tohru Tanaka

Inventor： Tohru Tanaka

IPC: A61K31/295 ,  C07C229/22 ,  A61P3/10 ,  A61P9/12 ,  A61P1/16 ,  A61P3/06 ,  A61P13/12 ,  A61P15/10 ,  A61K31/197

CPC classification number: A61K31/197 ,  A23L33/10 ,  A23L33/16 ,  A23L33/165 ,  A23L33/175 ,  A61K31/198 ,  A61K31/295 ,  A61K31/555 ,  A61K33/26 ,  A61K45/06 ,  A61K2300/00

Abstract: It is to provide a pharmaceutical composition which is different from an existing therapeutic agent of an adult disease, of a biochemical reaction-inhibiting type, and which action mechanism is to improve the basal metabolism, wherein the composition has no side effects, and does not generate drug resistance against adult disease; and a method for preventing/treating an adult disease by using the same. It is to provide a composition for preventing/ameliorating an adult disease such as metabolic syndrome, diabetes, hyperlipidemia, hypertension, impaired liver function, renal failure, adiposity, erectile dysfunction, menopausal disorder, shoulder discomfort, and low back pain, comprising 5-aminolevulinic acid (ALA), its derivative, or salt thereof, preferably comprising ALA, its derivative, or salt thereof, and an iron compound such as sodium ferrous citrate, iron sodium citrate and iron ammonium citrate; a food or food material for preventing/ameliorating an adult disease comprising the composition; and a method for using the composition for preparing an agent for preventing/ameliorating an adult disease.

Abstract translation: 本发明提供与生物化学反应抑制型的成人疾病的现有治疗剂不同的药物组合物，其作用机理是改善基础代谢，其中该组合物没有副作用，不 产生抗成年病的药物; 以及通过使用它们预防/治疗成人疾病的方法。 本发明提供一种用于预防/改善诸如代谢综合征，糖尿病，高脂血症，高血压，肝功能障碍，肾衰竭，肥胖，勃起功能障碍，绝经障碍，肩部不适和腰痛的成人疾病的组合物， 氨基乙酰丙酸（ALA），其衍生物或其盐，优选包含ALA，其衍生物或其盐，以及铁化合物如柠檬酸亚铁铵，柠檬酸铁钠和柠檬酸铁铵; 用于预防/改善包含该组合物的成人疾病的食品或食品材料; 以及使用该组合物制备用于预防/改善成人疾病的药剂的方法。

公开(公告)号：US20100173780A1

公开(公告)日：2010-07-08

申请号：US12376865

申请日：2007-07-18

Applicant: Masao Kondo ,  Naomi Aiba ,  Setsuko Miyanari ,  Masahiro Ishizuka ,  Tohru Tanaka

Inventor： Masao Kondo ,  Naomi Aiba ,  Setsuko Miyanari ,  Masahiro Ishizuka ,  Tohru Tanaka

IPC: C07C229/24 ,  A01N37/02

CPC classification number: A01N37/44

Abstract: To provide a polyphenol-content-increasing agent which increases the content of polyphenol in a plant. A polyphenol-content-increasing agent for plant, containing, as an active ingredient, a 5-aminolevulinic acid or a derivative thereof represented by the following formula (1):(Chem 1) R2R1NCH2COCH2CH2COR3   (1) wherein R1 and R2 each independently represents a hydrogen atom, an alkyl group, an acyl group, an alkoxycarbonyl group, an aryl group, or an aralkyl group; R3 represents a hydroxyl group, an alkoxy group which may have a substituent, an acyloxy group, an alkoxycarbonyloxy group, an aryloxy group, an aralkyloxy group, or an amino group, or a salt thereof.

Abstract translation: 提供增加植物中多酚含量的多酚含量增加剂。 含有下述式（1）所示的5-氨基乙酰丙酸或其衍生物作为活性成分的植物多酚含量增加剂：（化学式1）R2R1NCH2COCH2CH2COR3（1）其中R1和R2各自独立地表示 氢原子，烷基，酰基，烷氧基羰基，芳基或芳烷基; R3表示羟基，可以具有取代基的烷氧基，酰氧基，烷氧基羰基氧基，芳氧基，芳烷氧基或氨基，或其盐。

公开(公告)号：US20100035754A1

公开(公告)日：2010-02-11

申请号：US12513518

申请日：2008-03-28

Applicant: Keitaro Watanabe ,  Toshihiro Kobori ,  Tohru Tanaka ,  Kazuya Iwai

Inventor： Keitaro Watanabe ,  Toshihiro Kobori ,  Tohru Tanaka ,  Kazuya Iwai

IPC: A01N59/16 ,  A01N55/02

CPC classification number: A01N59/16 ,  A01N59/00 ,  A01N37/44 ,  A01N2300/00

Abstract: The present invention is directed to an agent for improving alkali tolerance of a plant and to a method for improving alkali tolerance of a plant through application of the agent to the plant.The agent for improving alkali tolerance of a plant is characterized by containing 5-aminolevulinic acid, a derivative thereof, or a salt of either of these and an iron compound. The method for improving alkali tolerance of plant is characterized by including treatment with the agent.

Abstract translation: 本发明涉及一种用于提高植物耐碱性的试剂和通过将该试剂施用于植物来提高植物耐碱性的方法。 用于提高植物耐碱性的试剂的特征在于含有5-氨基乙酰丙酸，其衍生物或它们中的任一种的盐和铁化合物。 提高植物耐碱性的方法，其特征在于包括用药剂处理。

公开(公告)号：US07615192B2

公开(公告)日：2009-11-10

申请号：US12075639

申请日：2008-03-13

Applicant: Yasuko Maruo ,  Shigeo Ogawa ,  Seizou Sakata ,  Tohru Tanaka

Inventor： Yasuko Maruo ,  Shigeo Ogawa ,  Seizou Sakata ,  Tohru Tanaka

IPC: G01N33/00

CPC classification number: G01N31/225 ,  G01N33/0039 ,  Y02A50/247 ,  Y10T436/206664

Abstract: A sensing element in which a dye that changes in the light absorption characteristic of the visible region upon reaction with ozone gas is deposited in the pores of a porous material is prepared. A change in dye before and after exposing the sensing element to a measurement environment for a predetermined time is measured. The ozone gas amount in measurement target air is measured on the basis of the change in dye.

Abstract translation: 制备其中在臭氧气体反应时将可见区的光吸收特性改变的染料沉积在多孔材料的孔中的感测元件。 测量在感测元件暴露于测量环境预定时间之前和之后染料的变化。 基于染料的变化来测量测量目标空气中的臭氧气体量。