发明授权
US5770390A Lipohaptens comprising a multifunctional substituted lipohilic carrier
linked to an antigen and their use
失效
Lipohaptens包含与抗原连接的多功能取代的脂质载体及其用途
- 专利标题: Lipohaptens comprising a multifunctional substituted lipohilic carrier linked to an antigen and their use
- 专利标题(中): Lipohaptens包含与抗原连接的多功能取代的脂质载体及其用途
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申请号: US621050申请日: 1996-03-22
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公开(公告)号: US5770390A公开(公告)日: 1998-06-23
- 发明人: Wilhelm Stoffel
- 申请人: Wilhelm Stoffel
- 申请人地址: IL Deerfield
- 专利权人: Dade International Inc.
- 当前专利权人: Dade International Inc.
- 当前专利权人地址: IL Deerfield
- 优先权: EPX88121536 19881222
- 主分类号: G01N33/531
- IPC分类号: G01N33/531 ; G01N33/543 ; G01N33/92 ; G01N33/545
摘要:
Lipohaptens of the general formula I (X).sub.m --R--Y--(S).sub.n --P (I) wherein R is a hydrocarbyl backbone having from 2 to 30 carbon atoms X is a hydrocarbyl radical having from 6 to 30 carbon atoms, which is linked to R via a bonding group containing one or more heteroatoms m is an integer from 1 to 5 P is a polypeptide or polysaccharide residue having from 2 to 100 aminoacid or glycosyl units Y is a functional group capable of binding to a free amino group of the polypeptide P or a carboxy, hemiacetal or hydroxy group of the polysaccharide P S is a difunctional spacer group, the functional groups thereof being capable of binding with the functional group Y on the one hand and a free amino, carboxy or hydroxy group of the polypeptide or polysaccaride P on the other hand, and n is 0 or 1 and their use in immunoreactions for determining antibodies and antigens, respectively.
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