公开(公告)号：US12227604B2

公开(公告)日：2025-02-18

申请号：US17291304

申请日：2019-11-06

Applicant: JSR CORPORATION

Inventor： Takanori Kishida ,  Takaya Nishida

IPC: C08F228/04 ,  B01D15/20 ,  B01D15/38 ,  B01J20/26 ,  B01J20/281 ,  B01J20/285 ,  B01J20/30 ,  C07C323/12 ,  C07D327/00 ,  C07K1/22 ,  C07K14/765 ,  C07K16/32 ,  C08F8/34 ,  C08F220/32 ,  C12N9/36 ,  G01N33/545

Abstract: A carrier which may have excellent pressure resistance, and even when a protein ligand is not immobilized thereon, a high dynamic binding capacity to a target substance, and a high performance of separating a target substance from a biological sample. Such a carrier may include a polymer having a crosslinked structure containing a divalent group of formula (1): wherein R1 to R4 are independently a single bond or divalent hydrocarbon group, R5 and R6 are independently H or a hydrocarbon group, X is a thio group, sulfinyl group, sulfonyl group, oxy group, >N(—R31), >Si(—R32)2, >P(—R33), >P(═O)(—R34), >B(—R35), or >C(—R36)2 (R31 to R36 independently being H or hydrocarbon group), and * is a bond, provided that when both R1 and R3 or both R2 and R4 are a divalent hydrocarbon group, respectively, R1 and R3 or R2 and R4 may form a ring together with an adjacent carbon atom.

公开(公告)号：US20240319178A1

公开(公告)日：2024-09-26

申请号：US18270429

申请日：2021-12-29

Applicant: Quest Diagnostics Investments LLC

Inventor： Mary Lapé Nixon

IPC: G01N33/543 ,  G01N33/545 ,  G01N33/569 ,  G01N33/576

CPC classification number: G01N33/54313 ,  G01N33/545 ,  G01N33/56911 ,  G01N33/5765 ,  G01N2333/08 ,  G01N2333/20 ,  G01N2469/20

Abstract: The present disclosure relates generally an immunoassay platform that utilizes a bead-based system to detect the presence or absence of antibodies in a test sample. The disclosed platform relates to methods and kits and can be used to detect the presence, absence, or exposure to Borrelia miyamotoi or Hepatitis D virus (HDV), or other pathogens or microbes of interest in a subject.

公开(公告)号：US20240301131A1

公开(公告)日：2024-09-12

申请号：US18663716

申请日：2024-05-14

Applicant: Beckman Coulter, Inc.

Inventor： Arunkumar Easwaran ,  Sergei Gulnik ,  Massimiliano Tomasulo

IPC: C08G61/10 ,  C09B69/10 ,  G01N33/533 ,  G01N33/542 ,  G01N33/545 ,  G01N33/58

CPC classification number: C08G61/10 ,  C09B69/105 ,  G01N33/533 ,  G01N33/542 ,  G01N33/545 ,  G01N33/582 ,  C08G2261/11 ,  C08G2261/1424 ,  C08G2261/1432 ,  C08G2261/145 ,  C08G2261/1644 ,  C08G2261/18 ,  C08G2261/228 ,  C08G2261/314 ,  C08G2261/78 ,  C08G2261/94

Abstract: Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.

公开(公告)号：US20240003890A1

公开(公告)日：2024-01-04

申请号：US18037279

申请日：2021-11-17

Applicant: Xibus Syetems, Inc.

Inventor： Timothy Manning Swager ,  Kent Harvey ,  Matthias Oberli

IPC: G01N33/58 ,  G01N33/543 ,  G01N33/545

CPC classification number: G01N33/582 ,  G01N33/54386 ,  G01N33/545

Abstract: Particle-based detection of analytes including, for example, systems, kits, and methods for growth, isolation, and/or monitoring of analytes are generally disclosed. In some embodiments, the systems and methods described herein are generally directed to the capture and/or concentrating of a target species (e.g., analyte) to be detected and/or monitored. In some embodiments, the materials, systems, and methods described herein may be used to create luminescent signals in response to the presence of selected analytes such as bacteria, viruses, and parasites. In some cases, the target analyte is a pathogenic bacteria, a pathogenic virus, a pathogenic parasite, or toxin.

公开(公告)号：US20230228769A1

公开(公告)日：2023-07-20

申请号：US18157250

申请日：2023-01-20

Applicant: FUJIFILM Corporation ,  OSAKA UNIVERSITY

Inventor： Eiji MIYOSHI ,  Koichi MORISHITA ,  Shinichiro SHINZAKI ,  Kei MOTOOKA ,  Kayoko KIDOWAKI ,  Ikumi TAMURA ,  Mutsuhiro DATE

IPC: G01N33/68 ,  G01N33/545

CPC classification number: G01N33/6893 ,  G01N33/545 ,  G01N2800/065 ,  G01N2470/04

Abstract: An object of the present invention is to provide a method of assisting diagnosis of inflammatory bowel disease, which can specifically determine inflammatory bowel disease.
The present invention relates to “a method of assisting diagnosis of inflammatory bowel disease, the method including subjecting a subject-derived specimen to a reduction treatment and subsequently measuring a human prohaptoglobin amount in the specimen by using an antibody 1 which is an antibody that specifically binds to an amino acid sequence set forth in SEQ ID NO: 1, and determining that a subject has inflammatory bowel disease by using the human prohaptoglobin amount as an indicator, and relates to an examination kit for assisting diagnosis of inflammatory bowel disease, including the antibody 1 a reducing agent”.

公开(公告)号：US20230192943A1

公开(公告)日：2023-06-22

申请号：US18094270

申请日：2023-01-06

Applicant: Beckman Coulter, Inc.

Inventor： Arunkumar Easwaran ,  Sergei Gulnik ,  Massimiliano Tomasulo

IPC: C08G61/10 ,  C09B69/10 ,  G01N33/533 ,  G01N33/542 ,  G01N33/545 ,  G01N33/58

CPC classification number: C08G61/10 ,  C09B69/105 ,  G01N33/533 ,  G01N33/542 ,  G01N33/545 ,  G01N33/582 ,  C08G2261/11 ,  C08G2261/18 ,  C08G2261/78 ,  C08G2261/94 ,  C08G2261/145 ,  C08G2261/228 ,  C08G2261/314 ,  C08G2261/1424 ,  C08G2261/1432 ,  C08G2261/1644

Abstract: Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.

公开(公告)号：US20230023831A1

公开(公告)日：2023-01-26

申请号：US17930649

申请日：2022-09-08

Applicant: BERKELEY LIGHTS, INC

Inventor： Kristin G. BEAUMONT ,  Peter J. BEEMILLER ,  Volker L.S. KURZ ,  Gregory G. LAVIEU ,  Xiaohua WANG ,  Aathavan KARUNAKARAN

IPC: G01N33/543 ,  B01L3/00 ,  G01N33/545 ,  G01N33/58

Abstract: In situ-generated microfluidic capture structures incorporating a solidified polymer network, methods of preparation and use, compositions and kits therefor are described. Microfluidic capture structures may be advantageously used for assays performed within the microfluidic environment, providing flexibility in assaying micro-objects such as biological cells. Assay reagents and analytes may be incorporated within the microfluidic capture structures.

公开(公告)号：US11378577B2

公开(公告)日：2022-07-05

申请号：US15772037

申请日：2016-10-31

Applicant: LSI MEDIENCE CORPORATION

Inventor： Tatsuya Yoshida ,  Yuhang Yang

IPC: G01N33/52 ,  G01N33/543 ,  G01N33/545

Abstract: Provided is a reagent for assaying a thrombin-antithrombin complex (TAT) in a blood sample from a subject by latex agglutination assay. The reagent includes a polycation. As a result, TAT complexes can be precisely assayed while circumventing the effect of heparin. The polycation is, for example, hexadimethrine bromide, chitosans, modified dextran, aminodextran, hydroxymethyl cellulose trimethylamine, lysozyme, spermine, spermidine, polylysine, polyarginine, polyornithine, protamine sulfate, hydroxyethyl cellulose trimethylamine, heparin-binding protein, polyallylamine, polyallylamine hydrochloride, poly(diallyl dialkyl amine), polyamideamine, polyamine, polyvinylbenzyltrimethylammonium chloride, polydiallyldimethylammonium chloride, polyethyleneimine, polypropyleneimine, polypropylethyleneimine, polyimidazoline, polyvinylamine, polyvinyl pyridine, poly(acrylamide/methacryloxypropyltrimethylammonium bromide), poly(diaryldimethylammonium chloride/N-isopropylacrylamide), poly(dimethylaminoethyl acrylate/acrylamide), poly(dimethylaminoethyl methacrylate), polydimethylaminoepichlorohydrin, polyethyleneiminoepichlorohydrin, polymethacryloxyethyl-trimethylammonium bromide, hydroxypropylmethacryloyloxyethyl dimethyl ammonium chloride, poly(methyldiethylaminoethylmethacrylate/acrylamide), poly(methyl/guanidine), polymethylvinylpyridinium bromide, poly(vinylpyrrolidone-dimethylaminoethyl methacrylate), or polyvinylmethylpyridinium bromide.

公开(公告)号：US20220146502A1

公开(公告)日：2022-05-12

申请号：US17427799

申请日：2020-01-31

Applicant: SENTILUS HOLDCO, LLC

Inventor： Reiner BABIEL ,  Tom FRAME ,  Sukanta BANERJEE ,  Tiruneh HAILEMARIAM ,  Hui HUANG ,  Efstathia MARINAKOS ,  Angus HUCKNALL ,  Vinalia TJONG

IPC: G01N33/545 ,  G01N33/569 ,  G01N33/80 ,  G01N33/543

Abstract: Disclosed herein are biological assays, screening formats, detection devices, and related methods of use. More specifically, disclosed herein are assay formats, microarrays, devices, methods of making the same, and methods of screening, detecting a target analyte, and methods of diagnosing an individual with a disease or condition when a target analyte associated with the disease or condition is detected.

公开(公告)号：US20220065848A1

公开(公告)日：2022-03-03

申请号：US17421119

申请日：2020-03-18

Applicant: Fianostics GmbH

Inventor： Albert Missbichler ,  Gerhard Hawa

IPC: G01N33/533 ,  G01N33/58 ,  G01N33/553 ,  G01N33/545 ,  C12N9/08 ,  C12N9/02 ,  C12N9/16

Abstract: The present invention relates to the use of a substrate for enhancing the chemiluminescence of one or more luminophores produced in a chemiluminescence reaction, wherein the substrate comprises a solid polymeric carrier with a plurality of depressions separated from one another and that the solid carrier is at least partially coated with a metal.