A buffer system for separating an aseptic fluid handling assembly from a drain includes a fluid receiving housing in fluid flow communication with a fluid discharge outlet of the aseptic fluid handling assembly. A trapped fluid discharge opening near the bottom of the housing, includes a tube which extends above the bottom into a baffle container. The baffle container is in the form of an enclosure having openings at the bottom thereof to admit fluids contained in the housing. A discharge conduit is in fluid flow communication with the discharge opening. A first fluid level detector in the housing activates at least one valve in the discharge conduit by a control which opens and closes the valve in response selected fluid levels detected by the fluid level detector. In a preferred embodiment the first fluid level detect detects a fluid level exceeding a preselected depth in the housing and a second fluid level detector detects fluid levels dropping below a second preselected level in the housing. Preferably the second fluid level detector is operatively connected to the valve to cause closing thereof in the event the fluid level drops below the second preselected level.