发明授权
US5785968A Anti-feline calicivirus recombinant antibody and gene fragment encoding
the same
失效
抗猫杯状病毒重组抗体和编码相同的基因片段
- 专利标题： Anti-feline calicivirus recombinant antibody and gene fragment encoding the same
- 专利标题（中）： 抗猫杯状病毒重组抗体和编码相同的基因片段
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申请号： US24253申请日： 1993-03-01
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公开(公告)号： US5785968A公开(公告)日： 1998-07-28
- 发明人: Kazuhiko Kimachi , Hiroaki Maeda , Kiyoto Nishiyama , Sachio Tokiyoshi , Yukinobu Tohya , Takeshi Mikami
- 申请人： Kazuhiko Kimachi , Hiroaki Maeda , Kiyoto Nishiyama , Sachio Tokiyoshi , Yukinobu Tohya , Takeshi Mikami
- 申请人地址： JPX Kumamoto
- 专利权人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
- 当前专利权人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
- 当前专利权人地址： JPX Kumamoto
- 优先权： JPX4-079189 19920228
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; C07K16/10 ; C12N15/13 ; C12P21/08 ; C07H21/04 ; A61K39/395 ; C07H16/00
摘要：
Anti-FCV (feline calicivirus) feline-type recombinant antibody effective for treatment, prevention and diagnosis of FCV infection and a gene fragment useful for preparation of said antibody are provided. Cell line 1D7 capable of producing a mouse monoclonal antibody having an excellent FCV-neutralizing activity was constructed and a gene fragment coding for the V region in charge of the FCV-specific binding of said antibody was obtained. This gene fragment and the gene coding for the constant region of the feline antibody are used to give a chimeric anti-FCV recombinant antibody. The obtained recombinant antibody is a novel antibody and is useful for the diagnosis, treatment and prevention of feline virus infections, particularly feline calicivirus infection, with high safety in administration into cats.
公开/授权文献
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