公开(公告)号：US5785968A

公开(公告)日：1998-07-28

申请号：US24253

申请日：1993-03-01

申请人： Kazuhiko Kimachi ,  Hiroaki Maeda ,  Kiyoto Nishiyama ,  Sachio Tokiyoshi ,  Yukinobu Tohya ,  Takeshi Mikami

发明人： Kazuhiko Kimachi ,  Hiroaki Maeda ,  Kiyoto Nishiyama ,  Sachio Tokiyoshi ,  Yukinobu Tohya ,  Takeshi Mikami

IPC分类号： A61K38/00 ,  C07K16/10 ,  C12N15/13 ,  C12P21/08 ,  C07H21/04 ,  A61K39/395 ,  C07H16/00

CPC分类号： C07K16/1045 ,  A61K38/00

摘要： Anti-FCV (feline calicivirus) feline-type recombinant antibody effective for treatment, prevention and diagnosis of FCV infection and a gene fragment useful for preparation of said antibody are provided. Cell line 1D7 capable of producing a mouse monoclonal antibody having an excellent FCV-neutralizing activity was constructed and a gene fragment coding for the V region in charge of the FCV-specific binding of said antibody was obtained. This gene fragment and the gene coding for the constant region of the feline antibody are used to give a chimeric anti-FCV recombinant antibody. The obtained recombinant antibody is a novel antibody and is useful for the diagnosis, treatment and prevention of feline virus infections, particularly feline calicivirus infection, with high safety in administration into cats.

摘要翻译： 提供了有效治疗，预防和诊断FCV感染的抗FCV（猫杯状病毒）猫科动物重组抗体和用于制备所述抗体的基因片段。 构建能够产生具有优异的FCV中和活性的小鼠单克隆抗体的细胞系1D7，得到编码负责所述抗体的FCV特异性结合的V区的基因片段。 使用该基因片段和编码猫抗体恒定区的基因得到嵌合抗FCV重组抗体。 获得的重组抗体是一种新的抗体，可用于诊断，治疗和预防猫病毒感染，特别是猫杯状病毒感染，对猫的施用具有高度的安全性。

公开(公告)号：US07326543B2

公开(公告)日：2008-02-05

申请号：US10863338

申请日：2004-06-09

申请人： Hiromi Ikadai ,  Ikuo Igarashi ,  Naoyoshi Suzuki ,  Hideyuki Nagasawa ,  Kozo Fujisaki ,  Takeshi Mikami

发明人： Hiromi Ikadai ,  Ikuo Igarashi ,  Naoyoshi Suzuki ,  Hideyuki Nagasawa ,  Kozo Fujisaki ,  Takeshi Mikami

IPC分类号： C12N15/09 ,  C12P21/04 ,  A61K39/002 ,  A61K39/015 ,  C07K1/00

CPC分类号： G01N33/56905 ,  C07K14/44 ,  C07K16/20 ,  Y10S530/822

摘要： The present invention provides a gene encoding a protein from merozoite of Babesia caballi, a recombinant protein of Babesia caballi, and an antibody capable specifically binding to a 48 kDa protein of rhoptry of Babesia caballi merozoite. In accordance with the present invention, it is possible to stably prepare the 48 kDa protein of rhoptry of Babesia caballi and the gene encoding said protein in a large amount with the recombinant DNA technique. The present invention also provides a method for diagnosing equine babesiasis which comprises either specifically detecting anti-Babesia caballi antibody present in equine blood by using the recombinant protein of present invention as an antigen or detecting the presence of Babesia caballi merozoite in equine blood by using the antibody of the present invention.

摘要翻译： 本发明提供了编码来自巴贝虫（Babesia caballi）的重组蛋白的巴贝虫（Babesia caballi）的裂殖子的蛋白质和能够特异性结合巴贝虫裂殖子的48kDa蛋白质的抗体的基因。 根据本发明，可以通过重组DNA技术稳定地制备巴贝氏菌的48kDa蛋白质和大量编码所述蛋白质的基因。 本发明还提供了一种用于诊断马贝氏病的方法，其特征在于，通过使用本发明的重组蛋白作为抗原或者通过使用本发明的马血中的巴贝虫突变体的存在来特异性检测马血中存在的抗巴贝虫抗体 本发明的抗体。

公开(公告)号：US4275145A

公开(公告)日：1981-06-23

申请号：US102514

申请日：1979-12-11

申请人： Takeshi Mikami

发明人： Takeshi Mikami

IPC分类号： G03C1/815 ,  G03C1/005 ,  G03C7/388 ,  G03C1/40 ,  G03C1/84

CPC分类号： G03C7/388 ,  G03C1/005

摘要： A method for dispersing an oil-soluble photographic additive into a hydrophilic colloid composition is disclosed wherein a solution of an oil-soluble photographic additive in an organic solvent or the melted oil-soluble photographic additive is dispersed in a hydrophilic colloid containing an anionic surface active agent and lecithin together with a gelatin derivative.

摘要翻译： 公开了将油溶性照相添加剂分散在亲水胶体组合物中的方法，其中油溶性照相添加剂在有机溶剂或熔融油溶性照相添加剂中的溶液分散在含有阴离子表面活性剂的亲水胶体中 药剂和卵磷脂以及明胶衍生物。

公开(公告)号：US4080209A

公开(公告)日：1978-03-21

申请号：US702322

申请日：1976-07-02

申请人： Yasuo Mukunoki ,  Takeshi Mikami ,  Nobuo Tsuji

发明人： Yasuo Mukunoki ,  Takeshi Mikami ,  Nobuo Tsuji

IPC分类号： G03C1/06 ,  G03C1/815 ,  G03C7/388 ,  G03C1/48 ,  G03C1/02

CPC分类号： G03C7/3885

摘要： A silver halide photographic light-sensitive material comprising a hydrophilic organic colloid layer containing a photographic additive dispersed therein using as a solvent a benzoic acid ester which has a boiling point of greater than 250.degree. C at atmospheric pressure, which is soluble in water in a proportion of less than about 10% by weight, and which dissolves water in a proportion of less than about 5% by weight. The benzoic acid ester does not have any harmful influence on the human body and does not cause environmental pollution.

摘要翻译： 一种卤化银照相感光材料，其包含在其中分散有照相添加剂的亲水性有机胶体层，其中使用在大气压下沸点大于250℃的苯甲酸酯，其溶于水中 比例小于约10重量％，并且其以小于约5重量％的比例溶解水。 苯甲酸酯对人体没有任何有害影响，不会造成环境污染。

公开(公告)号：US07879416B2

公开(公告)日：2011-02-01

申请号：US11442207

申请日：2006-05-26

申请人： Ken Hashimoto ,  Takatsugu Doi ,  Takeshi Mikami

发明人： Ken Hashimoto ,  Takatsugu Doi ,  Takeshi Mikami

IPC分类号： B41M5/50 ,  B41M5/52

CPC分类号： B41M5/0256 ,  B41J2/0057 ,  B41J11/002 ,  B41J2002/012 ,  B41M5/52 ,  B41M5/5218 ,  B82Y30/00 ,  C01P2002/02 ,  C01P2004/61 ,  C01P2004/62 ,  C01P2004/64 ,  C01P2006/12 ,  C09C1/0081 ,  C09C1/3072

摘要： The present invention provides ink receptive particles, for receiving an ink containing a recording material, the ink receptive particles comprising trap structures for trapping at least a liquid component of the ink, and a liquid absorbing resin. Using the ink receptive particles, the invention also provides a marking materials system, an ink receiving method, a recording method, a recording apparatus, and an ink receptive particle storage cartridge.

摘要翻译： 本发明提供了用于接收含有记录材料的油墨的油墨接收颗粒，该油墨接收颗粒包括用于捕集油墨的至少液体组分的捕获结构和液体吸收树脂。 本发明使用吸墨颗粒，还提供了标记材料系统，油墨接收方法，记录方法，记录装置和吸墨颗粒储存盒。

公开(公告)号：US4520091A

公开(公告)日：1985-05-28

申请号：US592863

申请日：1984-03-23

申请人： Fujio Kakimi ,  Takeshi Mikami

发明人： Fujio Kakimi ,  Takeshi Mikami

IPC分类号： G03G9/08 ,  B01J13/02 ,  G03G9/093

CPC分类号： G03G9/09378 ,  Y10T428/2984 ,  Y10T428/2989

摘要： An encapsulated electrostatographic toner material comprising a core and a shell enclosing the core, in which said core comprises:a colorant;a polymer;a solvent having a boiling point of not lower than 180.degree. C. which is capable of dissolving the polymer of causing the polymer to swell; andan organic liquid having a boiling point in the range of 100.degree. to 250.degree. C. which is substantially incapable of dissolving the polymer or causing the polymer to swell.

摘要翻译： 一种胶囊化的静电色调调色剂材料，包括芯和包封芯的外壳，其中所述芯包括：着色剂; 聚合物 沸点不低于180℃的溶剂，其能够溶解使聚合物膨胀的聚合物; 和沸点在100-250℃范围内的有机液体，其基本上不能溶解聚合物或引起聚合物溶胀。

公开(公告)号：US4468446A

公开(公告)日：1984-08-28

申请号：US432061

申请日：1982-09-30

申请人： Takeshi Mikami ,  Noriyuki Hosoi

发明人： Takeshi Mikami ,  Noriyuki Hosoi

IPC分类号： G03G9/08 ,  G03G9/093 ,  G03G13/20 ,  G03G9/16

CPC分类号： G03G9/09307 ,  G03G9/09328 ,  G03G9/09335

摘要： An electrostatographic toner material suitably employable for the pressure fixing process, which comprises encapsulated toner particles having an average particle size in the range from about 0.5 to 1,000 microns, in which the toner particle comprises a pressure fixable adhesive core material containing a colorant and a pressure rupturable shell enclosing the core material, the outer surface of the shell being provided with an organofluoro compound.

摘要翻译： 适合用于压力定影过程的静电调色剂材料，其包含平均粒径在约0.5至1,000微米范围内的包封的调色剂颗粒，其中调色剂颗粒包含含有着色剂的可压力粘合剂芯材料和压力 包封核心材料的可破裂外壳，外壳的外表面设置有有机氟化合物。

公开(公告)号：US4442194A

公开(公告)日：1984-04-10

申请号：US394637

申请日：1982-07-01

申请人： Takeshi Mikami

发明人： Takeshi Mikami

IPC分类号： G03G9/08 ,  B01J13/16 ,  G03G9/087 ,  G03G9/093 ,  B01J13/02

CPC分类号： B01J13/16 ,  G03G9/09328 ,  G03G9/09378 ,  G03G9/09392

摘要： A process for the preparation of an electrostatographic toner material comprising encapsulated toner particles which comprises:dispersing droplets of hydrophobic liquid having an average particle size in the range from about 0.5 to 1,000 microns and containing pressure fixable adhesive core material including colorant into a hydrophilic colloidal solution containing a gelatin derivative which is selected from the group consisting of a carboxylated gelatin, a sulfonylated gelatin, and an isocyanated gelatin;encapsulating the droplets with a polymerization reaction product of an active-hydrogen-containing compound with an acid chloride, a bischloroformate, a sulfonyl chloride, an isocyanate and/or an isothiocyanate; andseparating the encapsulated droplets from the hydrophilic colloidal solution to obtain the dry toner particles.

摘要翻译： 一种用于制备包含胶囊调色剂颗粒的静电色调调色剂材料的方法，其包括：将平均粒径在约0.5-1000微米范围内的疏水性液体的液滴分散，并将包含着色剂的压力可固定粘合剂芯材料分散在亲水胶体溶液 含有明胶衍生物，其选自羧化明胶，磺酰化明胶和异氰酸酯化明胶; 用含酰基氯，二氯甲酸酯，磺酰氯，异氰酸酯和/或异硫氰酸酯的含活性氢化合物的聚合反应产物包封液滴; 并将包封的液滴与亲水胶体溶液分离，得到干调色剂颗粒。

公开(公告)号：US4195999A

公开(公告)日：1980-04-01

申请号：US896870

申请日：1978-04-17

申请人： Keiichi Adachi ,  Shigeo Hirano ,  Tadashi Ikeda ,  Takeshi Mikami

发明人： Keiichi Adachi ,  Shigeo Hirano ,  Tadashi Ikeda ,  Takeshi Mikami

IPC分类号： G03C7/26 ,  C07D231/22 ,  C07D231/32 ,  C07D239/60 ,  C07D239/62 ,  C07D295/104 ,  C07D295/145 ,  G03C1/815 ,  G03C1/84 ,  G03C1/06 ,  G03C1/72 ,  G03C1/76

CPC分类号： C07D295/104 ,  C07D231/22 ,  C07D231/32 ,  C07D239/60 ,  C07D239/62 ,  C07D295/145 ,  G03C1/8155

摘要： A silver halide photographic material comprising a support having thereon at least one silver halide photographic emulsion layer with the silver halide photographic material containing, as an ultraviolet light absorbing agent, at least one compound having the general formula (I) ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, each represents a hydrogen atom, an alkyl group having 1 to 20 carbon atoms, or an aryl group having 6 to 20 carbon atoms, provided that the both of R.sub.1 and R.sub.2 do not simultaneously represent hydrogen atoms, and further, R.sub.1 and R.sub.2 can combine and form a cyclic amino group; R.sub.3 represents a carboxyl group, --COOR.sub.5, --COR.sub.5 or --SO.sub.2 R.sub.5, and R.sub.4 represents a carboxyl group, --COOR.sub.6, or --COR.sub.6 wherein R.sub.5 and R.sub.6, which may be the same or different, each represents an alkyl group having 1 to 20 carbon atoms, or an aryl group having 6 to 20 carbon atoms and further, R.sub.5 and R.sub.6 can combine together and form a 1,3-dioxocyclohexane nucleus, a barbituric acid nucleus, a 1,2-diaza-3,5-dioxocyclopentane nucleus, or a 2,4-diazo-1-alkoxy-3,5-dioxocyclohexene nucleus; n is an integer of 1 or 2 and when n is 2, at least one of R.sub.1, R.sub.2 and R.sub.6 may represent an alkylene or arylene group whereby the compound is a dimer; and a method of preventing the effects of ultraviolet light on a silver halide photographic material comprising incorporating into the silver halide photographic material, as an ultraviolet light absorbing agent, at least one compound having the general formula (I) above.

摘要翻译： 一种卤化银照相材料，其中含有至少一种卤化银照相乳剂层的支持体，其中卤化银照相材料含有作为紫外线吸收剂的至少一种具有通式（I）的化合物（I） 其中R 1和R 2可以相同或不同，各自表示氢原子，具有1-20个碳原子的烷基或具有6至20个碳原子的芳基，条件是R 1和R 2都不 同时代表氢原子，此外，R1和R2可以结合形成环氨基; R3表示羧基-COOR5，-COR5或-SO2R5，R4表示羧基-COOR6或-COR6，其中R5和R6可相同或不同，表示具有1〜20个碳原子的烷基 碳原子或具有6〜20个碳原子的芳基，此外，R5和R6可以结合在一起形成1,3-二氧环己烷核，巴比土酸核，1,2-二氮杂-3,5-二氧杂环戊烷核 ，或2,4-重氮-1-烷氧基-3,5-二氧环己烯核; n是1或2的整数，当n是2时，R 1，R 2和R 6中的至少一个可以表示亚烷基或亚芳基，由此化合物是二聚体; 以及防止紫外光对卤化银照相材料的影响的方法，包括将卤化银照相材料作为紫外线吸收剂，至少一种具有上述通式（I）的化合物。

公开(公告)号：US06398356B1

公开(公告)日：2002-06-04

申请号：US09497473

申请日：2000-02-04

申请人： Yuzuru Fukuda ,  Takeshi Mikami ,  Jiro Minabe ,  Yasufumi Suwabe

发明人： Yuzuru Fukuda ,  Takeshi Mikami ,  Jiro Minabe ,  Yasufumi Suwabe

IPC分类号： G01D1100

CPC分类号： C08L27/12 ,  C08L43/04 ,  C09D11/30 ,  C08L2666/04

摘要： A recording liquid including a colorant, water and at least two kinds of fine resin particles. In a preferred embodiment, at least one of the two kinds of the fine resin particles are fine self-crosslinkable resin particles. In another preferred embodiment, the number of the kinds of the fine resin particles is 3 or more. Also, disclosed is an image recording method using the recording liquid.

摘要翻译： 包含着色剂，水和至少两种细小树脂颗粒的记录液。 在优选的实施方案中，两种树脂微粒中的至少一种是精细的自交联树脂颗粒。 在另一个优选实施方式中，树脂微粒的种类数为3个以上。 此外，公开了使用该记录液体的图像记录方法。