A process for pipe system cleaning and in-line treatment of spent pipe system cleaning solution prior to disposal. A cleaning solution is added to a fouled pipe system to clean the pipe system of scale or deposits. The spent cleaning solution is recirculated through the cleaned pipe system and a treatment agent is added to the recirculating spent cleaning solution. The treatment agent is recirculated until the spent cleaning solution is environmentally safe for disposal. The in-line treatment process minimizes the volume of treated spent cleaning solution and minimizes the time required to treat the spent cleaning solution.