发明授权
US5807582A Fine-beaded colestipol hydrochloride and pharmaceutically elegant dosage
forms made therefrom
失效
精细串珠盐酸舍曲坦泊醇和由其制成的药学上优雅的剂型
- 专利标题： Fine-beaded colestipol hydrochloride and pharmaceutically elegant dosage forms made therefrom
- 专利标题（中）： 精细串珠盐酸舍曲坦泊醇和由其制成的药学上优雅的剂型
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申请号： US289141申请日： 1994-08-11
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公开(公告)号： US5807582A公开(公告)日： 1998-09-15
- 发明人: Dae Yang Cha
- 申请人： Dae Yang Cha
- 申请人地址： MI Kalamazoo
- 专利权人： Pharmacia & Upjohn Company
- 当前专利权人： Pharmacia & Upjohn Company
- 当前专利权人地址： MI Kalamazoo
- 主分类号： A61K31/785
- IPC分类号： A61K31/785 ; A61K9/14 ; A61K9/20
摘要：
The present invention provides for an improvement in the emulsion copolymerization process for the preparation of fine-beaded colestipol hydrochloride (FBCH) wherein the improvement comprises: 1) utilizing a weight ratio of water to polyethylenepolyamine in the process of 1.8 to 3.6 grams per gram, and 2) utilizing a weight ratio of surface active agent or surfactant to polyethylenepolyamine in the process of 1.0 to 3.0 grams per kilogram. The colestipol hydrochloride product thus produced is a novel fine-beaded form of a known pharmaceutical composition, yielding pharmaceutically elegant dosage forms exhibiting increased potency, including non-gritty oral powders and oral tablets. Conventional colestipol hydrochloride was heretofore available in large spherical granules which produced less elegant (gritty) oral suspensions.
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