发明授权
US5807745A Method of inhibiting PADGEM-mediated or ELAM-1-mediated leukocyte
adhesion using an inhibitor comprising a Le.sup.x core component
失效
使用包含Lex核心组分的抑制剂抑制PADGEM介导的或ELAM-1介导的白细胞粘附的方法
- 专利标题： Method of inhibiting PADGEM-mediated or ELAM-1-mediated leukocyte adhesion using an inhibitor comprising a Le.sup.x core component
- 专利标题（中）： 使用包含Lex核心组分的抑制剂抑制PADGEM介导的或ELAM-1介导的白细胞粘附的方法
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申请号： US379080申请日： 1995-01-26
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公开(公告)号： US5807745A公开(公告)日： 1998-09-15
- 发明人: Bruce Furie , Barbara C. Furie , Eric Larsen , Theresa Palabrica , Susan A. Sajer , Denisa D. Wagner
- 申请人： Bruce Furie , Barbara C. Furie , Eric Larsen , Theresa Palabrica , Susan A. Sajer , Denisa D. Wagner
- 申请人地址： MA Boston
- 专利权人： New England Medical Center Hospitals, Inc.
- 当前专利权人： New England Medical Center Hospitals, Inc.
- 当前专利权人地址： MA Boston
- 主分类号： C07K14/705
- IPC分类号： C07K14/705 ; C07K16/28 ; C12N5/00 ; C12N5/06
摘要：
The present invention relates to a method of inhibiting (reducing or preventing) the interaction of a cell which bears a surface molecule that interacts with a ligand comprising a Le.sup.x core with its target ligand by contacting the cell with an inhibitor comprising a Lewis x (Le.sup.x) core. The invention further relates to a method of inhibiting (reducing or preventing) the interaction or adhesion of endothelial cells and/or platelets with leukocytes (i.e., white blood cells), especially with nonlymphocytic leukocytes such as neutrophils and monocytes, by contacting the endothelial cells and/or platelets with an inhibitor comprising a Le.sup.x core under conditions whereby adhesion is inhibited.
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