发明授权
- 专利标题: C5A receptor antagonists having substantially no agonist activity
- 专利标题(中): 基本上没有激动剂活性的C5A受体拮抗剂
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申请号: US463224申请日: 1995-06-05
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公开(公告)号: US5807824A公开(公告)日: 1998-09-15
- 发明人: Jan van Oostrum , William C. Boyar , Nicholas G. Galakatos , Albert Schmitz , Gino Van Heeke
- 申请人: Jan van Oostrum , William C. Boyar , Nicholas G. Galakatos , Albert Schmitz , Gino Van Heeke
- 申请人地址: NY Tarrytown
- 专利权人: Ciba-Geigy Corporation
- 当前专利权人: Ciba-Geigy Corporation
- 当前专利权人地址: NY Tarrytown
- 主分类号: G01N33/566
- IPC分类号: G01N33/566 ; A61K38/00 ; A61K39/395 ; A61P1/00 ; A61P1/16 ; A61P9/08 ; A61P9/10 ; A61P11/00 ; A61P13/02 ; A61P15/00 ; A61P17/00 ; A61P19/06 ; A61P25/00 ; A61P25/28 ; A61P29/00 ; A61P31/04 ; A61P37/06 ; A61P43/00 ; C07H21/04 ; C07K14/47 ; C07K16/18 ; C12N1/19 ; C12N1/21 ; C12N5/10 ; C12N15/09 ; C12N15/12 ; C12P21/02 ; C12P21/08 ; C12R1/19 ; A61K38/16
摘要:
Disclosed are polypeptide analogues of human C5a which are C5a receptor antagonists that exhibit substantially no analphylatoxin or agonist activity, and derivatives of the analogues, and dimeric forms of the analogues or derivatives. DNA molecules encoding the polypeptides and methods of making the analogues are also provided. Pharmaceutical formulations containing a C5a analogue, are used therapeutically in the treatment of C5a-mediated diseases and inflammatory conditions in mammals, and prophylactically to prevent or reduce inflammation caused by an event which causes inflammation or aggravates an existing inflammatory condition, respectively. Further disclosed are antibodies specific to the C5a analogues, derivatives thereof, and dimers of the analogues and derivatives which exhibit substantially no cross-reactivity with human C5a. The antibodies are used to detect or quantify circulating C5a analogue or derivative, as well as to modify, e.g., neutralize, the activity of the C5a receptor antagonist in vivo.
公开/授权文献
- US4489784A Well control method using low-melting alloy metals 公开/授权日:1984-12-25