发明授权
US5808117A Process for the production of 16-Dehydropregenolone acetate form
diosgenin
失效
用于生产16-脱氢精氨酸龙血糖素形成薯di皂苷的方法
- 专利标题： Process for the production of 16-Dehydropregenolone acetate form diosgenin
- 专利标题（中）： 用于生产16-脱氢精氨酸龙血糖素形成薯di皂苷的方法
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申请号： US589708申请日： 1996-01-22
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公开(公告)号： US5808117A公开(公告)日： 1998-09-15
- 发明人: Pritish Kumar Chowdhury , Manobjyoti Bordoloi , Nabin Chandra Baraua , Heramba Prasad Sarmah , Pradip Kumar Goswami , Ram Prakash Saharma , Ajoy Pratap Baruah , Raj Kumar Mathur , Anil Chandra Ghosh
- 申请人： Pritish Kumar Chowdhury , Manobjyoti Bordoloi , Nabin Chandra Baraua , Heramba Prasad Sarmah , Pradip Kumar Goswami , Ram Prakash Saharma , Ajoy Pratap Baruah , Raj Kumar Mathur , Anil Chandra Ghosh
- 专利权人： Council of Scientific and Industrial Research (CSIR)
- 当前专利权人： Council of Scientific and Industrial Research (CSIR)
- 主分类号： C07J7/00
- IPC分类号： C07J7/00
摘要：
The invention relates to a process for producing 16-Dehydropregnenolone acetate (16DPA) of the formula shown below ##STR1## which process comprises a) acetolysis of diosgenin of the formula shown below ##STR2## by heating in a pressure reactor in the presence of an acetylating agent and a non-polar solvent, maintaining the pressure in the reactor in the range of 4-6 kg/cm.sup.2 and at a temperature in the range of 200.degree.-250.degree. C. to produce pseudodiosgenine acetate of the formula shown below ##STR3## b) Oxidizing the so obtained pseudodiosgenin acetate to obtain diosone of the formula shown below ##STR4## and, c) Hydrolysis and degradation of the diosone so obtained to produce the said 16-Dehydropregnenolone acetate.
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