公开(公告)号：US5808117A

公开(公告)日：1998-09-15

申请号：US589708

申请日：1996-01-22

申请人： Pritish Kumar Chowdhury ,  Manobjyoti Bordoloi ,  Nabin Chandra Baraua ,  Heramba Prasad Sarmah ,  Pradip Kumar Goswami ,  Ram Prakash Saharma ,  Ajoy Pratap Baruah ,  Raj Kumar Mathur ,  Anil Chandra Ghosh

发明人： Pritish Kumar Chowdhury ,  Manobjyoti Bordoloi ,  Nabin Chandra Baraua ,  Heramba Prasad Sarmah ,  Pradip Kumar Goswami ,  Ram Prakash Saharma ,  Ajoy Pratap Baruah ,  Raj Kumar Mathur ,  Anil Chandra Ghosh

IPC分类号： C07J7/00

CPC分类号： C07J7/00 ,  C07J13/005 ,  C07J7/0035 ,  C07J71/0005

摘要： The invention relates to a process for producing 16-Dehydropregnenolone acetate (16DPA) of the formula shown below ##STR1## which process comprises a) acetolysis of diosgenin of the formula shown below ##STR2## by heating in a pressure reactor in the presence of an acetylating agent and a non-polar solvent, maintaining the pressure in the reactor in the range of 4-6 kg/cm.sup.2 and at a temperature in the range of 200.degree.-250.degree. C. to produce pseudodiosgenine acetate of the formula shown below ##STR3## b) Oxidizing the so obtained pseudodiosgenin acetate to obtain diosone of the formula shown below ##STR4## and, c) Hydrolysis and degradation of the diosone so obtained to produce the said 16-Dehydropregnenolone acetate.

摘要翻译： 本发明涉及一种生产下文所示的16-去氢孕烯醇酮醋酸酯（16DPA）的方法，该方法包括：a）在压力反应器中，在 乙酰化剂和非极性溶剂，将反应器中的压力保持在4-6kg / cm 2的范围内，并在200-250℃的温度范围内，以产生下述式 b）氧化所得到的假性子糖过氧化物乙酸酯以获得下文所示的式子的二酮，并且c）如此获得的二酮的水解和降解以产生所述的16-脱氢孕烯醇酮醋酸酯。