发明授权
US5811454A 4-amino-fluorobenzamides and their use as cytotoxic prodrugs
失效
4-氨基 - 氟代苯甲酰胺及其作为细胞毒性前体药物的用途
- 专利标题： 4-amino-fluorobenzamides and their use as cytotoxic prodrugs
- 专利标题（中）： 4-氨基 - 氟代苯甲酰胺及其作为细胞毒性前体药物的用途
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申请号： US537890申请日： 1995-12-21
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公开(公告)号： US5811454A公开(公告)日： 1998-09-22
- 发明人: Caroline J. Springer
- 申请人： Caroline J. Springer
- 申请人地址： GBX London
- 专利权人： Cancer Research Campaign Technology Limited
- 当前专利权人： Cancer Research Campaign Technology Limited
- 当前专利权人地址： GBX London
- 优先权： GBX9308957 19930430
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K31/165 ; A61K31/195 ; A61K47/48 ; A61P35/00 ; A61P43/00 ; C07C229/60 ; C07C231/02 ; C07C237/36 ; C07C309/73 ; A61K31/235 ; C07C229/14
摘要：
The invention provides a compound which is a 3-fluorobenzamide of the formula (A) ##STR1## wherein R-NH is the residue of an .alpha.-amino acid R-NH.sub.2 or oligopeptide R-NH.sub.2, and M is a nitrogen mustard group of the formula ##STR2## wherein Y and L, which may be the same or different in a molecule, are leaving groups; or a pharmaceutically acceptable salt thereof. The compounds are useful as prodrugs for treating cancer.
公开/授权文献
- US5174993A Recombinant avipox virus and immunological use thereof 公开/授权日：1992-12-29