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206 条记录 (耗时 0.05 秒)

    AUTOMATED SYNTHESIS OF SMALL MOLECULES USING CHIRAL, NON-RACEMIC BORONATES
    3.
    发明申请
    AUTOMATED SYNTHESIS OF SMALL MOLECULES USING CHIRAL, NON-RACEMIC BORONATES 审中-公开

    公开(公告)号：US20190315676A1

    公开(公告)日：2019-10-17

    申请号：US16255453

    申请日：2019-01-23

    申请人： The Board of Trustees of the University of Illinois

    发明人： Martin D. Burke ,  Junqi Li ,  Eric P. Gillis

    IPC分类号： C07C229/14 ,  C07D207/16 ,  C07F5/02 ,  C07C229/24 ,  C07D211/60 ,  C07C227/32 ,  C07D207/44

    摘要： Provided are methods for making and using chiral, non-racemic protected organoboronic acids, including pinene-derived iminodiacetic acid (PIDA) boronates, to direct and enable stereoselective synthesis of organic molecules. Also provided are methods for purifying PIDA boronates from solution. Also provided are methods for deprotection of boronic acids from their PIDA ligands. The purification and deprotection methods may be used in conjunction with methods for coupling or otherwise reacting boronic acids. Iterative cycles of deprotection, coupling, and purification can be performed to synthesize chiral, non-racemic compounds. The methods are suitable for use in an automated chemical synthesis process. Also provided is an automated small molecule synthesizer apparatus for performing automated stereoselective synthesis of chiral, non-racemic small molecules using iterative cycles of deprotection, coupling, and purification.

    Synthesis, methods of using, and compositions of cycloalkylmethylamines
    8.
    发明授权
    Synthesis, methods of using, and compositions of cycloalkylmethylamines 有权
    合成，使用方法和环烷基甲基胺的组成

    公开(公告)号：US09302981B2

    公开(公告)日：2016-04-05

    申请号：US14203364

    申请日：2014-03-10

    申请人： Reviva Pharmaceuticals, Inc.

    发明人： Laxminarayan Bhat ,  Seema Rani Bhat

    IPC分类号： C07C229/34 ,  C07C229/14 ,  C07C271/16

    CPC分类号： C07C229/34 ,  C07C229/14 ,  C07C271/16 ,  C07C2601/04

    摘要： The present invention provides novel cycloalkylmethylamine analogs, and methods of preparing cycloalkylmethylamine analogs. The present invention also provides methods of using cycloalkylmethylamine analogs and compositions of cycloalkylmethylamine analogs. The pharmaceutical compositions of the compounds of the present invention can be advantageously used for treating and/or preventing obesity and obesity related co-morbid indications.

    摘要翻译： 本发明提供新的环烷基甲胺类似物，以及制备环烷基甲胺类似物的方法。 本发明还提供了使用环烷基甲胺类似物和环烷基甲胺类似物的组合物的方法。 本发明化合物的药物组合物可有利地用于治疗和/或预防肥胖和肥胖相关并发症的适应症。

    Antimicrobial Monomers and Polymers, and Their Use in Dental Devices
    9.
    发明申请
    Antimicrobial Monomers and Polymers, and Their Use in Dental Devices 有权
    抗菌单体和聚合物及其在牙科设备中的应用

    公开(公告)号：US20160068536A1

    公开(公告)日：2016-03-10

    申请号：US14782936

    申请日：2014-04-08

    申请人： Xiaoming XU ,  Stephen A. COSTIN

    发明人： Xiaoming Xu ,  Stephen Costin

    IPC分类号： C07D487/08 ,  A61K6/00 ,  C07C229/14

    CPC分类号： C07D487/08 ,  A61K6/0047 ,  C07C229/14 ,  A61K6/083 ,  C08L33/10

    摘要： Antimicrobial compounds are provided that are polymerizable. The compounds include monomers with antimicrobial properties. The compounds have cross-linking properties and are hydrolytically stable. The compounds may be utilized in dental and/or medical applications, including dental composites, dentures, bonding agents, sealants, resins and medical devices.

    摘要翻译： 提供可聚合的抗微生物化合物。 这些化合物包括具有抗微生物性质的单体。 该化合物具有交联性能并且具有水解稳定性。 这些化合物可以用于牙科和/或医学应用，包括牙科复合材料，义齿，粘合剂，密封剂，树脂和医疗装置。