发明授权
US5824520A Phage-display of immunoglobulin heavy chain libraries for identification
of inhibitors of intracellular constituents
失效
用于鉴定细胞内成分抑制剂的免疫球蛋白重链文库的噬菌体展示
- 专利标题： Phage-display of immunoglobulin heavy chain libraries for identification of inhibitors of intracellular constituents
- 专利标题（中）： 用于鉴定细胞内成分抑制剂的免疫球蛋白重链文库的噬菌体展示
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申请号： US897040申请日： 1997-07-19
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公开(公告)号： US5824520A公开(公告)日： 1998-10-20
- 发明人: Mary Jo Mulligan-Kehoe
- 申请人： Mary Jo Mulligan-Kehoe
- 申请人地址： DC Washington
- 专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址： DC Washington
- 主分类号： C07K16/00
- IPC分类号： C07K16/00 ; C12N15/10 ; C40B40/02 ; G01N33/68 ; C12P19/34 ; C12N15/13 ; C12N15/64 ; C12N15/79
摘要：
One aspect of the invention relates to a phage-display library that expresses single-chain recombinant binding proteins. Inserts in the library comprise immunoglobulin heavy chain framework regions flanking highly divergent, synthetically produced hypervariable regions. A second aspect of the invention relates to the use of single-chain recombinant binding proteins to inhibit the activity of an intracellular constituent. In the exemplary case presented, the activity of intracellular glucose-6-phosphate dehydrogenase was inhibited by intracellular expression of a cloned single-chain recombinant binding protein.
公开/授权文献
- US4164772A AC fault current limiting circuit 公开/授权日：1979-08-14
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