- 专利标题： TNF-.alpha. converting enzyme
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申请号： US655345申请日： 1996-05-23
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公开(公告)号： US5830742A公开(公告)日： 1998-11-03
- 发明人: Roy A. Black , Charles Rauch , Carl J. March , Douglas P. Cerretti
- 申请人： Roy A. Black , Charles Rauch , Carl J. March , Douglas P. Cerretti
- 申请人地址： WA Seattle
- 专利权人： Immunex Corporation
- 当前专利权人： Immunex Corporation
- 当前专利权人地址： WA Seattle
- 主分类号： C07K16/40
- IPC分类号： C07K16/40 ; C12N9/64 ; C12N1/00 ; C12N5/10 ; C12Q1/37
摘要：
A metalloprotease that converts TNF-.alpha. from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.
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