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1.发明申请POLYPEPTIDES THAT BIND TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE (TIMP-3), COMPOSITIONS AND METHODS 审中-公开金属蛋白酶三类（TIMP-3），组合物和方法的结合组织抑制剂的多肽公开(公告)号：US20120231013A1
公开(公告)日：2012-09-13
申请号：US13388242
申请日：2010-07-29
申请人： Roy A. Black , Peng Li , Joshua Silverman , Chadwick T. King
发明人： Roy A. Black , Peng Li , Joshua Silverman , Chadwick T. King
CPC分类号： C07K14/81 , A61K38/00 , A61K38/57 , C07K7/08 , C07K14/8146 , C07K16/38 , C07K2317/21 , C07K2317/76
摘要： The present invention relates to TIMP-3 binding compositions, methods of producing such compositions, and methods of using such compositions, including in the treatment of various conditions.
摘要翻译： 本发明涉及TIMP-3结合组合物，制备这种组合物的方法，以及使用这些组合物的方法，包括在各种条件的治疗中。
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公开(公告)号：US06406901B1
公开(公告)日：2002-06-18
申请号：US09579766
申请日：2000-05-26
IPC分类号： C12N950
CPC分类号： C12N9/6489 , C07K16/40
摘要： A metalloprotease that converts TNF-&agr; from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.
摘要翻译： 已经分离和纯化将来自26kD细胞形式的TNF-α转化为17kD形式的金属蛋白酶，并且已知cDNA序列。 特别地，蛋白酶的分子量约为80kD。 分离和纯化的蛋白酶可用于设计其抑制剂，可用作治疗剂。 用于检测分子的蛋白酶抑制活性的测定法也是本发明的一个方面。
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公开(公告)号：US06555354B2
公开(公告)日：2003-04-29
申请号：US09726968
申请日：2000-11-29
IPC分类号： C12N948
CPC分类号： C12N9/6489 , C07K16/40
摘要： A metalloprotease that converts TNF-&agr; from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.
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4.发明授权Interleukin 1.beta. protease and interleukin 1.beta. protease inhibitors 失效白细胞介素1β蛋白酶和白细胞介素1β蛋白酶抑制剂
公开(公告)号：US5416013A
公开(公告)日：1995-05-16
申请号：US203716
申请日：1994-02-28
IPC分类号： A61K38/00 , C07C271/22 , C07K5/02 , C07K5/06 , C07K7/06 , C07K14/545 , C12N9/64 , C12N15/57
CPC分类号： C07K7/06 , C07C271/22 , C07K14/545 , C07K5/0202 , C07K5/06191 , C12N9/6475 , A61K38/00
摘要： There is disclosed an isolated polypeptide and derivatives thereof having protease biological activity for human precursor IL-1.beta. and for a substrate comprising:R.sub.1 - Asp - R .sub.2 - R.sub.3wherein R.sub.1 and R.sub.3 are independently any D or L isomer amino acid, R.sub.2 is Ala or Gly, and wherein the specific protease cleavage site is between Asp and R.sub.2. Inhibitor compounds, compositions and methods for inhibiting Interleukin 1.beta. protease activity are also disclosed. The inhibitor compounds comprise an amino acid sequence of from 1 to about 5 amino acids having an N-terminal blocking group and a C-terminal Asp residue connected to an electronegative leaving group, wherein the amino acid sequence corresponds to the sequence Ala-Tyr-Val-His-Asp.
摘要翻译： 公开了具有对人前体IL-1β和底物具有蛋白酶生物学活性的分离的多肽及其衍生物，其包含：R1-Asp-R2-R3，其中R1和R3独立地为任何D或L异构体氨基酸，R 2为 Ala或Gly，并且其中特异性蛋白酶切割位点在Asp和R2之间。 还公开了抑制剂化合物，组合物和抑制白介素1β蛋白酶活性的方法。 抑制剂化合物包含具有N-末端封闭基团的1至约5个氨基酸的氨基酸序列和与电负离子基团连接的C末端Asp残基，其中氨基酸序列对应于序列Ala-Tyr- Val-His-Asp。
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公开(公告)号：US07695948B2
公开(公告)日：2010-04-13
申请号：US11709436
申请日：2007-02-21
IPC分类号： C12N9/48
CPC分类号： C12N9/6489 , C07K16/40
摘要： A metalloprotease that converts TNF-α from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.
摘要翻译： 将TNF-α从26kD细胞形式转化为17kD形式的金属蛋白酶已被分离并纯化，cDNA序列已知。 特别地，蛋白酶的分子量约为80kD。 分离和纯化的蛋白酶可用于设计其抑制剂，可用作治疗剂。 用于检测分子的蛋白酶抑制活性的测定法也是本发明的一个方面。
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公开(公告)号：US20090247605A1
公开(公告)日：2009-10-01
申请号：US11824227
申请日：2007-06-28
IPC分类号： A61K31/7088 , C12Q1/37 , G01N33/53
CPC分类号： C12N9/6489 , A61K38/00 , C12Y304/24086 , G01N33/6893
摘要： This invention relates to the identification of membrane-associated proteins shed by metalloproteinases and in particular by TNF-alpha converting enzyme (TACE), to the use of such metalloproteinase-shed proteins in assays for TACE agonists and antagonists, and to the use of metalloproteinase agonists and antagonists, and particularly TACE agonists and antagonists, in the treatment of diseases mediated by certain shed proteins.
摘要翻译： 本发明涉及通过金属蛋白酶，特别是TNF-α转换酶（TACE）脱落的膜相关蛋白的鉴定，涉及在TACE激动剂和拮抗剂的测定中使用这种金属蛋白酶脱落蛋白，以及使用金属蛋白酶 激动剂和拮抗剂，特别是TACE激动剂和拮抗剂，用于治疗由某些脱落蛋白介导的疾病。
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公开(公告)号：US07199224B2
公开(公告)日：2007-04-03
申请号：US10423729
申请日：2003-04-25
申请人： Roy A Black , Charles Rauch , Carl J March , Douglas P Cerretti
发明人： Roy A Black , Charles Rauch , Carl J March , Douglas P Cerretti
IPC分类号： C07K16/00
CPC分类号： C12N9/6489 , C07K16/40
摘要： A metalloprotease that converts TNF-α from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.
摘要翻译： 已经分离和纯化将来自26kD细胞形式的TNF-α转化为17kD形式的金属蛋白酶，并且已知cDNA序列。 特别地，蛋白酶的分子量约为80kD。 分离和纯化的蛋白酶可用于设计其抑制剂，可用作治疗剂。 用于检测分子的蛋白酶抑制活性的测定法也是本发明的一个方面。
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公开(公告)号：US07074408B2
公开(公告)日：2006-07-11
申请号：US09792200
申请日：2001-02-23
CPC分类号： C12N9/6489 , A61K38/00 , C07K14/705
摘要： The present invention provides methods and compositions for inhibiting the biological activity of integrins, for inhibiting endothelial cell migration. and for inhibiting angiogenesis. In particular, the invention provides compositions comprising ADAM disintegrin domains and methods for using said compositions. In preferred embodiments the methods and compositions of the invention are used to inhibit angiogenesis and to treat diseases or conditions mediated by angiogenesis.
摘要翻译： 本发明提供用于抑制整联蛋白的生物学活性的方法和组合物，用于抑制内皮细胞迁移。 并用于抑制血管发生。 特别地，本发明提供包含ADAM去整合素结构域的组合物和使用所述组合物的方法。 在优选的实施方案中，本发明的方法和组合物用于抑制血管发生和治疗由血管发生介导的疾病或病症。
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公开(公告)号：US06842704B2
公开(公告)日：2005-01-11
申请号：US09244984
申请日：1999-02-04
申请人： Roy A. Black , Raymond James Paxton , Wolfram Bode , Klaus Maskos , Carlos Fernandez-Catalan , James Ming Chen , Jeremy Ian Levin
发明人： Roy A. Black , Raymond James Paxton , Wolfram Bode , Klaus Maskos , Carlos Fernandez-Catalan , James Ming Chen , Jeremy Ian Levin
CPC分类号： C12N9/6489
摘要： A tumor necrosis factor-α converting enzyme (TACE) is produced, purified, and crystallized. The three-dimensional coordinates of the crystal are obtained by X-ray diffraction. The coordinates can be recorded on a computer readable medium, or are part of a video memory, where they can be used as part of a system for studying for studying TACE. The coordinates are also used in designing, screening, and developing compounds that associate with TACE.
摘要翻译： 产生，纯化和结晶的肿瘤坏死因子-α转化酶（TACE）。 通过X射线衍射获得晶体的三维坐标。 坐标可以被记录在计算机可读介质上，或者是视频存储器的一部分，它们可以用作用于研究TACE的系统的一部分。 坐标也用于设计，筛选和开发与TACE相关的化合物。
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公开(公告)号：US6013466A
公开(公告)日：2000-01-11
申请号：US183275
申请日：1998-10-30
CPC分类号： C12N9/6489 , C07K16/40
摘要： A metalloprotease that converts TNF-.alpha. from the 26 kD cell form to the 17 kD form has been isolated and purified and the cDNA sequence known. In particular, the protease has a molecular weight of approximately 80 kD. The isolated and purified protease is useful for designing an inhibitor thereof, and may find use as a therapeutic agent. Assays for detecting the protease-inhibiting activity of a molecule are also an aspect of the invention.
摘要翻译： 已经分离和纯化将TNF-α从26kD细胞形式转化为17kD形式的金属蛋白酶，并且已知cDNA序列。 特别地，蛋白酶的分子量约为80kD。 分离和纯化的蛋白酶可用于设计其抑制剂，可用作治疗剂。 用于检测分子的蛋白酶抑制活性的测定法也是本发明的一个方面。
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