发明授权
US5830892A Piperidine and morphonline derivatives and their use as therapeutic
agents
失效
哌啶和吗啉衍生物及其作为治疗剂的用途
- 专利标题: Piperidine and morphonline derivatives and their use as therapeutic agents
- 专利标题(中): 哌啶和吗啉衍生物及其作为治疗剂的用途
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申请号: US981294申请日: 1997-12-18
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公开(公告)号: US5830892A公开(公告)日: 1998-11-03
- 发明人: Raymond Baker , Jason Matthew Elliott , Graeme Irvine Stevenson , Christopher John Swain
- 申请人: Raymond Baker , Jason Matthew Elliott , Graeme Irvine Stevenson , Christopher John Swain
- 申请人地址: GB3 Hoddesdon
- 专利权人: Merck Sharp & Dohme Ltd.
- 当前专利权人: Merck Sharp & Dohme Ltd.
- 当前专利权人地址: GB3 Hoddesdon
- 优先权: GBX9513117 19950628
- 主分类号: A61K31/4427
- IPC分类号: A61K31/4427 ; A61K31/445 ; A61P1/00 ; A61P9/00 ; A61P25/00 ; A61P29/00 ; A61P35/00 ; A61P37/08 ; A61P43/00 ; C07D401/14 ; A61K31/535 ; C07D401/12 ; C07D413/12
摘要:
The present invention provides compounds of formula (I), wherein R.sup.1 is a 5- or 6-membered aromatic heterocyclic group containing 1, 2, 3 or 4 heteroatoms selected from nitrogen, oxygen and sulphur, which group is optionally substituted; R.sup.2 is hydrogen, halogen, C.sub.1-6 alkyl, C.sub.1-6 alkoxy, CF.sub.3, OCF.sub.3, NO.sub.2, CN, SR.sup.a, SOR.sup.a, SO.sub.2 R.sup.a, CO.sub.2 R.sup.a, CONR.sup.a R.sup.b, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl or C.sub.1-4 alkyl substitued by C.sub.1-4 alkoxy, where R.sup.a and R.sup.a R.sup.b each independently represent hydrogen or C.sub.1-4 alkyl; R.sup.3 is hydrogen, halogen, C.sub.1-6 alkyl, C.sub.1-6 -alkoxy substituted by C.sub.1-4 alkoxy or CF.sub.3 ; R.sup.4, R.sup.5, R.sup.6, R.sup.9a, R.sup.9b, A, X and Y are as defined in the specification; and m is zero or , and pharmaceutically acceptable salts and prodrugs thereof. The compounds are of particular use in the treatment or prevention of pain, inflammation, migraine, emesis and pos therpetic neuralgia.
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