发明授权
- 专利标题： Diagnostic method employing MSH2 protein
- 专利标题（中）： 采用MSH2蛋白的诊断方法
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申请号： US457374申请日： 1995-06-01
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公开(公告)号： US5837443A公开(公告)日： 1998-11-17
- 发明人: Albert de la Chapelle , Bert Vogelstein , Kenneth W. Kinzler
- 申请人： Albert de la Chapelle , Bert Vogelstein , Kenneth W. Kinzler
- 申请人地址： MD Baltimore
- 专利权人： The Johns Hopkins University
- 当前专利权人： The Johns Hopkins University
- 当前专利权人地址： MD Baltimore
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K48/00 ; C07K14/82 ; C12Q1/68 ; C12Q1/25 ; C07K14/47
摘要：
The human MSH2 gene, responsible for hereditary non-polyposis colorectal cancer, was identified by virtue of its homology to the MutS class of genes, which are involved in DNA mismatch repair. The sequence of cDNA clones of the human gene are provided, and the sequence of the gene can be used to demonstrate the existence of germ line mutations in hereditary non-polyposis colorectal cancer (HNPCC) kindreds, as well as in replication error.sup.+ (RER.sup.+) tumor cells.
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