发明授权
- 专利标题: Assay method for screening for inhibitors of proTNF conversion
- 专利标题(中): 用于筛选proTNF转化抑制剂的测定方法
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申请号: US394600申请日: 1995-02-27
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公开(公告)号: US5843693A公开(公告)日: 1998-12-01
- 发明人: Robert F. Halenbeck , Michael Kriegler , Carl Perez , David A. Jewell , Kirston E. Koths
- 申请人: Robert F. Halenbeck , Michael Kriegler , Carl Perez , David A. Jewell , Kirston E. Koths
- 申请人地址: CA Emeryville
- 专利权人: Chiron Corporation
- 当前专利权人: Chiron Corporation
- 当前专利权人地址: CA Emeryville
- 主分类号: A61K38/00
- IPC分类号: A61K38/00 ; C07K5/06 ; C07K14/525 ; C07K14/81 ; C07K16/40 ; C12N9/50 ; C12N9/64 ; C12N9/99 ; C12Q1/37
摘要:
Methods and materials are disclosed for the production of purified, active recombinant human neutrophil protease, PR-3, via activation of a pro-form herein referred to as proPR-3. Human PR-3 is useful for discovering inhibitors of excessive release of mature, active TNF.alpha.. Also disclosed are methods for the identification of inhibitors of the conversion of the pro-form of TNF.alpha. to its mature active form.
公开/授权文献
- US6108291A Optical disc apparatus accessing method and system therefor 公开/授权日:2000-08-22