发明授权
- 专利标题： Transmission-blocking vaccine against malaria
- 专利标题（中）： 传播阻断疫苗针对疟疾
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申请号： US365997申请日： 1994-12-29
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公开(公告)号： US5853739A公开(公告)日： 1998-12-29
- 发明人: David C. Kaslow , Philip J. Barr
- 申请人： David C. Kaslow , Philip J. Barr
- 申请人地址： DC Washington CA Emeryville
- 专利权人： The United States of America as represented by the Department of Health and Human Services,Chiron Corporation
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services,Chiron Corporation
- 当前专利权人地址： DC Washington CA Emeryville
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K39/00 ; C07K14/445 ; C12N15/86 ; A61K39/015 ; C12N15/00 ; C12N7/00 ; C12P21/02
摘要：
The present invention relates to transmission-blocking vaccines against malaria. Vaccines of the present invention contain a recombinant Pfs25 Plasmodium falciparum protein produced by yeast cells and to yeast cells producing the protein. Mice and monkeys inoculated with the yeast-expressed Pfs25 of the present invention have developed antibodies with transmission-blocking activity. The present invention also relates to methods of preventing or treating malarial infections using the vaccines of the present invention.
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