发明授权
- 专利标题： 9-N-ethenyl derivatives of 9(S)-erythromycylamine
- 专利标题（中）： 9（S） - 红霉素胺的9-N-乙烯基衍生物
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申请号： US956352申请日： 1997-10-23
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公开(公告)号： US5854219A公开(公告)日： 1998-12-29
- 发明人: Nedjeljko Kujundzic , Dina Pavlovic , Gabrijela Kobrehel , Gorjana Lazarevski , Zeljko Kelneric
- 申请人： Nedjeljko Kujundzic , Dina Pavlovic , Gabrijela Kobrehel , Gorjana Lazarevski , Zeljko Kelneric
- 申请人地址： HRX Zagreb
- 专利权人： PLIVA, farmaceutska, kemijska, prehrambena i kozmeticka industrija, dionicko drustvo
- 当前专利权人： PLIVA, farmaceutska, kemijska, prehrambena i kozmeticka industrija, dionicko drustvo
- 当前专利权人地址： HRX Zagreb
- 优先权： HRXP960497A 19961028
- 主分类号： A61K31/70
- IPC分类号： A61K31/70 ; A61K31/7042 ; A61K31/7048 ; A61P31/04 ; C07H17/08 ; C07D315/00 ; C07G11/00
摘要：
The invention relates to 9-N-ethenyl derivatives of 9 (S)-erythromycylamine, new semisynthetic antibiotics of the macrolide class of the general formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and represent nitryl, a carboxyl group of the formula COOR.sup.3, wherein R.sup.3 represents a C.sub.1 -C.sub.4 alkyl group, or a keto group of the formula COR.sup.4, wherein R.sup.4 represents a C.sub.1 -C.sub.4 alkyl group, to their pharmaceutically acceptable addition salts with inorganic or organic acids, to a process for their preparation, to a process for the preparation of the pharmaceutical compositions as well as to the use of the obtained pharmaceutical compositions in the treatment of bacterial infections.
公开/授权文献
- US5323187A Image compression system by setting fixed bit rates 公开/授权日：1994-06-21