发明授权
- 专利标题： Azetidine, pyrrolidine and piperidine derivatives
- 专利标题（中）： 氮杂环丁烷，吡咯烷，哌啶衍生物
-
申请号： US776024申请日： 1997-01-22
-
公开(公告)号： US5854268A公开(公告)日： 1998-12-29
- 发明人: Raymond Baker , Sylvie Bourrain , Jose Luis Castro Pineiro , Mark Stuart Chambers , Alexander Richard Guiblin , Sarah Christine Hobbs , Richard Alexander Jelley , Andrew Madin , Victor Giulio Matassa , Austin John Reeve , Michael Geoffrey Russell , Graham Andrew Showell , Francine Sternfeld , Leslie Joseph Street , Monique Bodil Van Niel
- 申请人： Raymond Baker , Sylvie Bourrain , Jose Luis Castro Pineiro , Mark Stuart Chambers , Alexander Richard Guiblin , Sarah Christine Hobbs , Richard Alexander Jelley , Andrew Madin , Victor Giulio Matassa , Austin John Reeve , Michael Geoffrey Russell , Graham Andrew Showell , Francine Sternfeld , Leslie Joseph Street , Monique Bodil Van Niel
- 申请人地址： GB2 Hoddesdon
- 专利权人： Merck Sharp & Dohme, Ltd.
- 当前专利权人： Merck Sharp & Dohme, Ltd.
- 当前专利权人地址： GB2 Hoddesdon
- 优先权： GBX9415552 19940802; GBX9415579 19940802; GBX9426375 19941221
- 主分类号： C07D401/14
- IPC分类号： C07D401/14 ; A61K31/41 ; A61K31/44 ; A61K31/4427 ; A61K31/443 ; A61K31/4433 ; A61K31/445 ; A61K31/475 ; A61P9/00 ; A61P25/04 ; A61P43/00 ; C07D403/14 ; C07D405/14 ; C07D409/14 ; C07D471/04 ; C07D521/00
摘要：
A class of substituted azetidine, pyrrolidine and piperidine derivatives are selective agonists of 5-HT.sub.1 -like receptors, being potent agonists of the human 5-HT.sub.1D.alpha. receptor subtype whilst possessing at least a 10-fold selective affinity for the 5-HT.sub.1D.alpha. receptor subtype relative to the 5-HT.sub.1D.beta. subtype; they are therefore useful in the treatment and/or prevention of clinical conditions, in particular migraine and associated disorders, for which a subtype-selective agonist of 5-HT.sub.1D receptors is indicated, whilst eliciting fewer side-effects, notably adverse cardiovascular events, than those associated with non-subtype-selective 5-HT.sub.1D receptor agonists.
公开/授权文献
- US4117056A Production of beta-alumina ceramic articles 公开/授权日：1978-09-26
信息查询
