发明授权
US5856184A Isolated domains of type IV collagen to modify cell and tissue
interactions
失效
IV型胶原的分离结构域，以修饰细胞和组织相互作用
- 专利标题： Isolated domains of type IV collagen to modify cell and tissue interactions
- 专利标题（中）： IV型胶原的分离结构域，以修饰细胞和组织相互作用
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申请号： US800965申请日： 1997-02-18
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公开(公告)号： US5856184A公开(公告)日： 1999-01-05
- 发明人: Michael P. Sarras, Jr. , Billy G. Hudson
- 申请人： Michael P. Sarras, Jr. , Billy G. Hudson
- 申请人地址： CT New Haven KS Kansas City
- 专利权人： Yale University,University of Kansas Medical Center
- 当前专利权人： Yale University,University of Kansas Medical Center
- 当前专利权人地址： CT New Haven KS Kansas City
- 主分类号： A61K38/39
- IPC分类号： A61K38/39 ; A61M5/32 ; A61P43/00 ; C07K16/18 ; C12N5/00 ; C12N5/08
摘要：
The instant invention demonstrates that the 7S domain of type IV collagen disrupts cell aggregation and tissue development. Structural changes in mesoglea, inhibition of cell proliferation, and changes in cell differentiation patterns accompanies the blockage of cell aggregates which indicate that blockage may be due to alterations in mesoglea (extracellular matrix) structure with accompanying effects on cell behavior. Type IV collagen has a critical role in the initial formation of mesoglea and that perturbation of mesoglea formation affects cell division, cell differentiation, and morphogenesis.