发明授权
US5856318A Nitrogen-containing cyclohetero cyclo-heteroaminoaryl derivatives for
CNS disorders
失效
用于CNS疾病的含氮环杂环芳基芳基衍生物
- 专利标题: Nitrogen-containing cyclohetero cyclo-heteroaminoaryl derivatives for CNS disorders
- 专利标题(中): 用于CNS疾病的含氮环杂环芳基芳基衍生物
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申请号: US910302申请日: 1997-08-11
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公开(公告)号: US5856318A公开(公告)日: 1999-01-05
- 发明人: Wayne Bowen , Brian R. de Costa , Celia Dominguez , Xiao-Shu He , Kenner C. Rice
- 申请人: Wayne Bowen , Brian R. de Costa , Celia Dominguez , Xiao-Shu He , Kenner C. Rice
- 申请人地址: DC Washington
- 专利权人: The United States of America as represented by the Department of Health and Human Services
- 当前专利权人: The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址: DC Washington
- 主分类号: C07D207/14
- IPC分类号: C07D207/14 ; C07D211/56 ; C07D223/12 ; C07D409/06 ; A61K31/33 ; A61K31/55 ; C07D295/00 ; C07D405/00
摘要:
Certain nitrogen-containing cyclohetero cycloalkylaminoaryl compounds are described for treatment of CNS disorders such as cerebral ischemia, psychoses and convulsions. Compounds of particular interest are of the formula: ##STR1## wherein each of R.sup.1, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 is independently selected from hydrido, lower alkyl, benzyl, and haloloweralkyl;wherein each of R.sup.2, R.sup.3 and R.sup.8 through R.sup.11 is independently selected from hydrido, hydroxy, loweralkyl, benzyl, phenoxy, benzyloxy and haloloweralkyl; wherein n is an integer of from four to six; wherein m is an integer of from two to four; wherein A is selected from phenyl, naphthyl, benzothienyl, benzofuranyl and thienyl; wherein any of the foregoing A groups can be further substituted with one or more substituents independently selected from hydrido, hydroxy, loweralkyl, loweralkoxy, halo, haloloweralkyl, amino, monoloweralkylamino and diloweralkylamino; or a pharmaceutically acceptable salt thereof.