公开(公告)号：US07637414B2

公开(公告)日：2009-12-29

申请号：US12171903

申请日：2008-07-11

申请人： Timothy Brooks Bambridge ,  John Wayne Bowen ,  John McKenna Brennan ,  Joseph Michael Freund

发明人： Timothy Brooks Bambridge ,  John Wayne Bowen ,  John McKenna Brennan ,  Joseph Michael Freund

IPC分类号： B23K31/00

CPC分类号： H01L24/49 ,  H01L23/66 ,  H01L24/48 ,  H01L2223/6644 ,  H01L2224/4809 ,  H01L2224/48091 ,  H01L2224/49111 ,  H01L2224/49175 ,  H01L2924/00014 ,  H01L2924/01033 ,  H01L2924/01082 ,  H01L2924/14 ,  H01L2924/19041 ,  H01L2924/19107 ,  H01L2924/3011 ,  Y10T29/49144 ,  Y10T29/49147 ,  Y10T29/49149 ,  Y10T29/49162 ,  Y10T29/49179 ,  Y10T29/49194 ,  H01L2224/45099 ,  H01L2224/05599

摘要： An integrated circuit is wire bonded in a manner such that there is consistent RF performance from integrated circuit package to integrated circuit package. Bond distances within the integrated circuit are measured, each corresponding to a wire bond to be formed. An area under a hypothetical wire bond profile is calculated as a function of the bond distances, a baseline wire length, and a baseline loop height. A wire is bonded across a given one of the bond distances to form a given one of the wire bonds. A wire bond profile for the given wire bond is provided having an area thereunder that is substantially equal to the calculated area.

摘要翻译： 一种集成电路是以从集成电路封装到集成电路封装的射频性能一致的方式引线接合的。 测量集成电路内的结合距离，每个对应于要形成的引线键合。 根据键距，基线长度和基线回路高度，计算假想线接合曲线下的面积。 导线沿着给定的一个焊接距离结合以形成给定的一个引线键合。 提供给定引线键合的引线键合分布，其具有基本上等于所计算的面积的区域。

公开(公告)号：US07086148B2

公开(公告)日：2006-08-08

申请号：US10787010

申请日：2004-02-25

申请人： Timothy Brooks Bambridge ,  John Wayne Bowen ,  John McKenna Brennan ,  Joseph Michael Freund

发明人： Timothy Brooks Bambridge ,  John Wayne Bowen ,  John McKenna Brennan ,  Joseph Michael Freund

IPC分类号： H05K3/00

CPC分类号： H01L24/49 ,  H01L23/66 ,  H01L24/48 ,  H01L2223/6644 ,  H01L2224/4809 ,  H01L2224/48091 ,  H01L2224/49111 ,  H01L2224/49175 ,  H01L2924/00014 ,  H01L2924/01033 ,  H01L2924/01082 ,  H01L2924/14 ,  H01L2924/19041 ,  H01L2924/19107 ,  H01L2924/3011 ,  Y10T29/49144 ,  Y10T29/49147 ,  Y10T29/49149 ,  Y10T29/49162 ,  Y10T29/49179 ,  Y10T29/49194 ,  H01L2224/45099 ,  H01L2224/05599

摘要： An integrated circuit is wire bonded in a manner such that there is consistent RF performance from integrated circuit package to integrated circuit package. Bond distances within the integrated circuit are measured, each corresponding to a wire bond to be formed. An area under a hypothetical wire bond profile is calculated as a function of the bond distances, a baseline wire length, and a baseline loop height. A wire is bonded across a given one of the bond distances to form a given one of the wire bonds. A wire bond profile for the given wire bond is provided having an area thereunder that is substantially equal to the calculated area.

公开(公告)号：US20060004036A1

公开(公告)日：2006-01-05

申请号：US11181797

申请日：2005-07-15

申请人： Wayne Bowen ,  Keith Crawford ,  James Hildreth

发明人： Wayne Bowen ,  Keith Crawford ,  James Hildreth

IPC分类号： A61K31/485

CPC分类号： A61K31/485 ,  A61K31/00 ,  A61K31/435 ,  A61K31/44

摘要： The present invention relates to sigma-2 receptor agonists and their use in the treatment of immunodeficiency virus infections, especially human immunodeficiency virus (HIV) infections. The invention particularly relates to sigma-2 agonists, especially CB-184 and its analogues, that decrease cellular production of sphingomyelin when provided to recipient cells, and inhibit HIV replication.

摘要翻译： 本发明涉及σ-2受体激动剂及其在治疗免疫缺陷病毒感染，特别是人类免疫缺陷病毒（HIV）感染）中的用途。 本发明特别涉及当提供给受体细胞时减少鞘磷脂的细胞产生并抑制HIV复制的σ-2激动剂，特别是CB-184及其类似物。

公开(公告)号：US20050232756A1

公开(公告)日：2005-10-20

申请号：US10823933

申请日：2004-04-14

申请人： Nathan Cormier ,  Wayne Bowen ,  James Rhoda ,  Mitchell Headley

发明人： Nathan Cormier ,  Wayne Bowen ,  James Rhoda ,  Mitchell Headley

IPC分类号： F01D9/04 ,  F01D17/16 ,  F01D25/24 ,  F03B1/04 ,  F04D29/56

CPC分类号： F04D29/563 ,  F01D17/162 ,  Y10T403/587

摘要： A method facilitates assembling a variable vane assembly for a gas turbine engine including a casing and an inner shroud. The method comprises providing at least one variable vane including a radially inner spindle that includes a groove defined therein that has at least one machined face, and coupling the variable vane radially between the casing and the inner shroud such that at least a portion of the radially inner spindle is inserted at least partially through an opening extending radially through the inner shroud. The method also comprises securing the variable vane to the inner shroud by engaging the spindle machined face with a retainer coupled to the inner shroud.

摘要翻译： 一种方法便于组装用于包括壳体和内护罩的燃气涡轮发动机的可变叶片组件。 该方法包括提供包括径向内心轴的至少一个可变叶片，所述径向内心轴包括限定在其中的凹槽，其具有至少一个加工面，并且将可变叶片径向地联接在壳体和内护罩之间，使得至少一部分径向 内心轴至少部分地穿过径向延伸穿过内护罩的开口。 该方法还包括通过将主轴加工的面与与内护罩连接的保持器接合来将可变叶片固定到内护罩。

公开(公告)号：US06517811B2

公开(公告)日：2003-02-11

申请号：US09755366

申请日：2001-01-05

申请人： Christy S. John ,  Jesse Baumgold ,  John G. McAfee ,  Terry Moody ,  Wayne Bowen

发明人： Christy S. John ,  Jesse Baumgold ,  John G. McAfee ,  Terry Moody ,  Wayne Bowen

IPC分类号： A61K5100

CPC分类号： C07B59/00 ,  A61K51/0406 ,  C07B2200/05 ,  C07D295/13 ,  C07D307/79

摘要： The present invention relates to a class of compounds having affinity for certain cancer cells, e.g. lung carcinomas, colon carcinomas, renal carcinomas, prostate carcinomas, breast carcinomas, malignant melanomas, gliomas, neuroblastomas and pheochromocytomas. The compounds of the present invention can also bind with high specificity to cell surface sigma receptors and can therefore be used for diagnostic imaging of any tissue having an abundance of cells with sigma receptors. The present invention provides such compounds as agents for diagnostic imaging and for detecting and treating tumors containing the cancer cells described above.

摘要翻译： 本发明涉及对某些癌细胞具有亲和力的一类化合物，例如， 肺癌，结肠癌，肾癌，前列腺癌，乳腺癌，恶性黑素瘤，神经胶质瘤，成神经细胞瘤和嗜铬细胞瘤。 本发明的化合物也可以以高特异性结合细胞表面σ受体，因此可用于具有西格玛受体细胞丰度的任何组织的诊断成像。 本发明提供了用于诊断成像和用于检测和治疗含有上述癌细胞的肿瘤的化合物。

公开(公告)号：US6140886A

公开(公告)日：2000-10-31

申请号：US257014

申请日：1999-02-25

申请人： Roger Anthony Fratti ,  John Wayne Bowen ,  Melvin West

发明人： Roger Anthony Fratti ,  John Wayne Bowen ,  Melvin West

IPC分类号： H03H7/42 ,  H01P5/10

CPC分类号： H01P5/10

摘要： A transmission line balun transformer for providing a single ended output signal from a pair of differential input signals includes two transmission line signal couplers. The couplers are individually designed to be relatively loosely coupled devices, i.e. having a coupling factor greater than 3 dB, but are coupled together with proper phase relationships so as to achieve a relatively tighter composite coupling characteristic in the order of 3 dB, thereby resulting in an increase in bandwidth.

摘要翻译： 用于从一对差分输入信号提供单端输出信号的传输线平衡不平衡变压器包括两个传输线信号耦合器。 耦合器被单独设计成相对松散耦合的装置，即具有大于3dB的耦合因子，但是以适当的相位关系耦合在一起，以便实现3dB的相对更紧密的复合耦合特性，从而导致 带宽增加。

公开(公告)号：US5856318A

公开(公告)日：1999-01-05

申请号：US910302

申请日：1997-08-11

申请人： Wayne Bowen ,  Brian R. de Costa ,  Celia Dominguez ,  Xiao-Shu He ,  Kenner C. Rice

发明人： Wayne Bowen ,  Brian R. de Costa ,  Celia Dominguez ,  Xiao-Shu He ,  Kenner C. Rice

IPC分类号： C07D207/14 ,  C07D211/56 ,  C07D223/12 ,  C07D409/06 ,  A61K31/33 ,  A61K31/55 ,  C07D295/00 ,  C07D405/00

CPC分类号： C07D409/06 ,  C07D207/14 ,  C07D211/56 ,  C07D223/12

摘要： Certain nitrogen-containing cyclohetero cycloalkylaminoaryl compounds are described for treatment of CNS disorders such as cerebral ischemia, psychoses and convulsions. Compounds of particular interest are of the formula: ##STR1## wherein each of R.sup.1, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 is independently selected from hydrido, lower alkyl, benzyl, and haloloweralkyl;wherein each of R.sup.2, R.sup.3 and R.sup.8 through R.sup.11 is independently selected from hydrido, hydroxy, loweralkyl, benzyl, phenoxy, benzyloxy and haloloweralkyl; wherein n is an integer of from four to six; wherein m is an integer of from two to four; wherein A is selected from phenyl, naphthyl, benzothienyl, benzofuranyl and thienyl; wherein any of the foregoing A groups can be further substituted with one or more substituents independently selected from hydrido, hydroxy, loweralkyl, loweralkoxy, halo, haloloweralkyl, amino, monoloweralkylamino and diloweralkylamino; or a pharmaceutically acceptable salt thereof.

摘要翻译： 描述某些含氮环杂环烷基氨基芳基化合物用于治疗中枢神经系统疾病如脑缺血，精神病和抽搐。 特别感兴趣的化合物具有下式：其中R 1，R 4，R 5，R 6和R 7各自独立地选自氢，低级烷基，苄基和卤代低级烷基; 其中R2，R3和R8至R11各自独立地选自氢，羟基，低级烷基，苄基，苯氧基，苄氧基和卤代低级烷基; 其中n为4-6的整数; 其中m是2至4的整数; 其中A选自苯基，萘基，苯并噻吩基，苯并呋喃基和噻吩基; 其中前述A基团中的任一个可以进一步被一个或多个独立地选自氢，羟基，低级烷基，低级烷氧基，卤素，卤代低级烷基，氨基，单低级烷基氨基和二低级烷基氨基的取代基取代。 或其药学上可接受的盐。

公开(公告)号：US5679679A

公开(公告)日：1997-10-21

申请号：US348654

申请日：1994-12-02

申请人： Wayne Bowen ,  Brian R. de Costa ,  Celia Dominguez ,  Xiao-Shu He ,  Kenner C. Rice

发明人： Wayne Bowen ,  Brian R. de Costa ,  Celia Dominguez ,  Xiao-Shu He ,  Kenner C. Rice

IPC分类号： A61K31/495 ,  C07D471/04 ,  C07D487/04 ,  C07D31/495 ,  C07D31/55

CPC分类号： C07D471/04 ,  A61K31/495 ,  C07D487/04

摘要： Certain aralkyl diazabicyloalkyl compounds are described for treatment of CNS disorders such as cerebral ischemia, psychoses and convulsions. Compounds of particular interest are of the formula: ##STR1## wherein: each of R.sup.1, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 is independently selected from the group consisting of hydrido, loweralkyl, benzyl and haloloweralkyl; each of R.sup.2, R.sup.3, and R.sup.8 through R.sup.11 is independently selected from the group consisting of hydrido, hydroxy, loweralkyl, benzyl, phenoxy, benzyloxy and haloloweralkyl; n is an integer of from three to four; m is an integer of two; A is selected from the group consisting of phenyl, naphthyl, benzothienyl, benzofuranyl and thienyl and wherein any of the foregoing A groups can be further substituted with one or more substituents independently selected from the group consisting of hydrido, hydroxy, loweralkyl, loweralkoxy, halo, haloloweralkyl, amino, monoloweralkylamino and diloweralkylamino; or a pharmaceutically acceptable salt thereof.

摘要翻译： 描述了某些芳烷基二氮杂双环烷基化合物用于治疗中枢神经系统疾病如脑缺血，精神病和抽搐。 特别感兴趣的化合物具有下式：其中：R 1，R 4，R 5，R 6和R 7各自独立地选自氢，低级烷基，苄基和卤代低级烷基; R 2，R 3和R 8至R 11各自独立地选自氢，羟基，低级烷基，苄基，苯氧基，苄氧基和卤代低级烷基; n是3至4的整数; m是2的整数; A选自苯基，萘基，苯并噻吩基，苯并呋喃基和噻吩基，其中任何前述A基团可以进一步被一个或多个独立地选自羟基，羟基，低级烷基，低级烷氧基，卤代 ，卤代低级烷基，氨基，单低级烷基氨基和二低级烷基氨基; 或其药学上可接受的盐。

公开(公告)号：US5679673A

公开(公告)日：1997-10-21

申请号：US344304

申请日：1994-11-21

申请人： Wayne Bowen ,  Brian R. de Costa ,  Celia Dominguez ,  Xiao-Shu He ,  Kenner C. Rice

发明人： Wayne Bowen ,  Brian R. de Costa ,  Celia Dominguez ,  Xiao-Shu He ,  Kenner C. Rice

IPC分类号： C07D453/02 ,  C07D487/08 ,  A61K31/55 ,  C07D471/08

CPC分类号： C07D487/08 ,  C07D453/02

摘要： Certain aralkyl diazabicycloalkyl compounds are described for treatment of CNS disorders such as cerebral ischemia, psychoses and convulsions. Compounds of particular interest are of the formula: ##STR1## wherein each of R, R.sup.1, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 is independently selected from hydrido, lower-alkyl, benzyl, and haloloweralkyl; wherein each of R.sup.2, R.sup.3 and R.sup.10 through R.sup.13 is independently selected from hydrido, hydroxy, loweralkyl, benzyl, phenoxy, benzyloxy and haloloweralkyl; wherein each of R.sup.8 and R.sup.9 is selected from hydrido, loweralkyl, benzyl and haloloweralkyl; wherein m is an integer of from two to four; wherein A is selected from phenyl, naphthyl, benzothiophenyl, benzofuranyl and thienyl; wherein any of the foregoing A groups can be further substituted with one or more substituents independently selected from hydrido, hydroxy, loweralkyl, loweralkoxy, halo, haloloweralkyl, amino, monoloweralkylamino and diloweralkylamino; or a pharmaceutically acceptable salt thereof.

摘要翻译： 描述了某些芳烷基二氮杂双环烷基化合物用于治疗中枢神经系统疾病如脑缺血，精神病和抽搐。 特别感兴趣的化合物具有下式：其中R，R 1，R 4，R 5，R 6和R 7各自独立地选自氢，低级烷基，苄基和卤代低级烷基; 其中R2，R3和R10至R13各自独立地选自氢，羟基，低级烷基，苄基，苯氧基，苄氧基和卤代低级烷基; 其中R8和R9各自选自氢，低级烷基，苄基和卤代低级烷基; 其中m是2至4的整数; 其中A选自苯基，萘基，苯并噻吩基，苯并呋喃基和噻吩基; 其中前述A基团中的任一个可以进一步被一个或多个独立地选自氢，羟基，低级烷基，低级烷氧基，卤素，卤代低级烷基，氨基，单低级烷基氨基和二低级烷基氨基的取代基取代。 或其药学上可接受的盐。

公开(公告)号：US5346908A

公开(公告)日：1994-09-13

申请号：US904354

申请日：1992-06-25

申请人： Wayne Bowen ,  Brian R. de Costa ,  Celia Dominguez ,  Xiao-Shu He ,  Kenner C. Rice

发明人： Wayne Bowen ,  Brian R. de Costa ,  Celia Dominguez ,  Xiao-Shu He ,  Kenner C. Rice

IPC分类号： C07D207/14 ,  C07D211/56 ,  C07D223/12 ,  C07D409/06 ,  A61K31/55 ,  A61K31/40 ,  A61K31/445 ,  C07D211/08

CPC分类号： C07D409/06 ,  C07D207/14 ,  C07D211/56 ,  C07D223/12

摘要： Certain nitrogen-containing cyclohetero cycloalkylaminoaryl compounds are described for treatment of CNS disorders such as cerebral ischemia, psychoses and convulsions. Compounds of particular interest are of the formula: ##STR1## wherein each of R.sup.1, R.sup.4, R.sup.5, R.sup.6 and R.sup.7 is independently selected from hydrido, lower alkyl, benzyl, and haloloweralkyl; wherein each of R.sup.2, R.sup.3 and R.sup.8 through R.sup.11 is independently selected from hydrido, hydroxy, loweralkyl, benzyl, phenoxy, benzyloxy and haloloweralkyl; wherein n is an integer of from four to six; wherein m is an integer of from two to four; wherein A is selected from phenyl, naphthyl, benzothienyl, benzofuranyl and thienyl; wherein any of the foregoing A groups can be further substituted with one or more substituents independently selected from hydrido, hydroxy, loweralkyl, loweralkoxy, halo, haloloweralkyl, amino, monoloweralkylamino and diloweralkylamino; or a pharmaceutically acceptable salt thereof.

摘要翻译： 描述某些含氮环杂环烷基氨基芳基化合物用于治疗中枢神经系统疾病如脑缺血，精神病和抽搐。 特别感兴趣的化合物具有下式：其中R 1，R 4，R 5，R 6和R 7各自独立地选自氢，低级烷基，苄基和卤代低级烷基; 其中R2，R3和R8至R11各自独立地选自氢，羟基，低级烷基，苄基，苯氧基，苄氧基和卤代低级烷基; 其中n为4-6的整数; 其中m是2至4的整数; 其中A选自苯基，萘基，苯并噻吩基，苯并呋喃基和噻吩基; 其中前述A基团中的任一个可以进一步被一个或多个独立地选自氢，羟基，低级烷基，低级烷氧基，卤素，卤代低级烷基，氨基，单低级烷基氨基和二低级烷基氨基的取代基取代。 或其药学上可接受的盐。