发明授权
- 专利标题： Salts of azelastine having improved solubility
- 专利标题（中）： 具有改善溶解性的氮卓斯汀盐
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申请号： US691415申请日： 1996-08-02
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公开(公告)号： US5859003A公开(公告)日： 1999-01-12
- 发明人: Helmut Hettche , Reinhard Muckenschnabel , Gerhard Scheffler , Ilona Fleischhauer , Wolfgang Morick
- 申请人： Helmut Hettche , Reinhard Muckenschnabel , Gerhard Scheffler , Ilona Fleischhauer , Wolfgang Morick
- 申请人地址： DEX Frankfurt
- 专利权人： Asta Pharma Aktiengesellschaft
- 当前专利权人： Asta Pharma Aktiengesellschaft
- 当前专利权人地址： DEX Frankfurt
- 优先权： DEX3914859.9 19890505
- 主分类号： A61K31/50
- IPC分类号： A61K31/50 ; A61K31/55 ; A61P11/00 ; A61P29/00 ; A61P37/08 ; A61P43/00 ; C07D403/04
摘要：
The present invention relates to salts of azelastine having improved solubility in water. The salts of the present invention are prepared by reacting azelastine with acetic acid, gluconic acid, lactic acid or malic acid. A pharmaceutical composition may be prepared containing an azelastine salt and a pharmaceutically-acceptable carrier or diluent therefor. The pharmaceutical composition is useful in the treatment of allergies, asthma, inflammatory and psoriasis disorders and provides a cytoprotective effect.
公开/授权文献
- US4528949A Fluid injection apparatus for internal combustion engines 公开/授权日：1985-07-16
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