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公开(公告)号：US5859003A
公开(公告)日：1999-01-12
申请号：US691415
申请日：1996-08-02
申请人： Helmut Hettche , Reinhard Muckenschnabel , Gerhard Scheffler , Ilona Fleischhauer , Wolfgang Morick
发明人： Helmut Hettche , Reinhard Muckenschnabel , Gerhard Scheffler , Ilona Fleischhauer , Wolfgang Morick
CPC分类号： C07D403/04 , A61K31/55 , Y10S514/863 , Y10S514/886 , Y10S514/887
摘要： The present invention relates to salts of azelastine having improved solubility in water. The salts of the present invention are prepared by reacting azelastine with acetic acid, gluconic acid, lactic acid or malic acid. A pharmaceutical composition may be prepared containing an azelastine salt and a pharmaceutically-acceptable carrier or diluent therefor. The pharmaceutical composition is useful in the treatment of allergies, asthma, inflammatory and psoriasis disorders and provides a cytoprotective effect.
摘要翻译： 本发明涉及在水中具有改善的溶解性的氮卓斯汀盐。 本发明的盐通过将萘曲斯汀与乙酸，葡萄糖酸，乳酸或苹果酸反应来制备。 可以制备药物组合物，其含有氮卓斯坦盐及其药学上可接受的载体或稀释剂。 药物组合物可用于治疗过敏，哮喘，炎性和银屑病，并提供细胞保护作用。
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公开(公告)号：US20080311210A1
公开(公告)日：2008-12-18
申请号：US12040290
申请日：2008-02-29
CPC分类号： A61K36/482 , A61K31/704 , A61K36/68 , A61K2300/00
摘要： The invention relates to a pharmaceutical composition which is suitable in particular for use as purgative (cathartic), where the composition comprises in combination and in each case in pharmaceutically effective amounts (A) senna fruit dry extract and (B) plantago seeds (plantaginis ovatae semen). The composition can advantageously be manufactured by fluidized bed granulation. The composition is in particular free of guar gum, is dust-free, is dispersible in water and has a pleasant taste and can be supplemented straightforwardly with vitamins, minerals, trace elements and the like.
摘要翻译： 本发明涉及一种药物组合物，其特别适合用作泻药（泻药），其中组合物组合包含药学有效量（A）番泻奈果干提取物和（B）车前草种子（plantaginis ovatae 精液）。 组合物可以有利地通过流化床造粒制备。 该组合物特别是没有瓜尔胶，无尘，可分散在水中并具有令人愉快的味道，并可直接补充维生素，矿物质，微量元素等。
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公开(公告)号：US07611736B2
公开(公告)日：2009-11-03
申请号：US12420602
申请日：2009-04-08
CPC分类号： A61K36/482 , A61K31/704 , A61K36/68 , A61K2300/00
摘要： The invention relates to a pharmaceutical composition which is suitable in particular for use as purgative (cathartic), where the composition comprises in combination and in each case in pharmaceutically effective amounts (A) senna fruit dry extract and (B) plantago seeds (plantaginis ovatae semen). The composition can advantageously be manufactured by fluidized bed granulation. The composition is in particular free of guar gum, is dust-free, is dispersible in water and has a pleasant taste and can be supplemented straightforwardly with vitamins, minerals, trace elements and the like.
摘要翻译： 本发明涉及一种药物组合物，其特别适合用作泻药（泻药），其中组合物组合包含药学有效量（A）番泻奈果干提取物和（B）车前草种子（plantaginis ovatae 精液）。 组合物可以有利地通过流化床造粒制备。 该组合物特别是没有瓜尔胶，无尘，可分散在水中并具有令人愉悦的味道，并可直接补充维生素，矿物质，微量元素等。
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公开(公告)号：US20090186106A1
公开(公告)日：2009-07-23
申请号：US12420602
申请日：2009-04-08
CPC分类号： A61K36/482 , A61K31/704 , A61K36/68 , A61K2300/00
摘要： The invention relates to a pharmaceutical composition which is suitable in particular for use as purgative (cathartic), where the composition comprises in combination and in each case in pharmaceutically effective amounts (A) senna fruit dry extract and (B) plantago seeds (plantaginis ovatae semen). The composition can advantageously be manufactured by fluidized bed granulation. The composition is in particular free of guar gum, is dust-free, is dispersible in water and has a pleasant taste and can be supplemented straightforwardly with vitamins, minerals, trace elements and the like.
摘要翻译： 本发明涉及一种药物组合物，其特别适合用作泻药（泻药），其中组合物组合包含药学有效量（A）番泻奈果干提取物和（B）车前草种子（plantaginis ovatae 精液）。 组合物可以有利地通过流化床造粒制备。 该组合物特别是没有瓜尔胶，无尘，可分散在水中并具有令人愉快的味道，并可直接补充维生素，矿物质，微量元素等。
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5.发明授权Method of treating inflammatory disorders and psoriasis with salts of azelastine 失效用AZELASTINE治疗炎症性疾病和PSORIASIS的方法
公开(公告)号：US5086050A
公开(公告)日：1992-02-04
申请号：US652986
申请日：1991-02-08
申请人： Helmut Hettche , Reinhard Muckenschnabel , Gerhard Scheffler , Ilona Fleischhauer , Wolfgang Morick
发明人： Helmut Hettche , Reinhard Muckenschnabel , Gerhard Scheffler , Ilona Fleischhauer , Wolfgang Morick
CPC分类号： C07D403/04 , A61K31/55 , Y10S514/863 , Y10S514/886 , Y10S514/887
摘要： Salts of azelastine with acetic acid, gluconic acid, lactic acid or malic acid.
摘要翻译： 萘曲宁与醋酸，葡萄糖酸，乳酸或苹果酸的盐。
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公开(公告)号：US20090110759A1
公开(公告)日：2009-04-30
申请号：US12140102
申请日：2008-06-16
CPC分类号： A61K36/482 , A61K31/704 , A61K36/68 , A61K2300/00
摘要： The invention relates to a pharmaceutical composition which is suitable in particular for use as purgative (cathartic), where the composition comprises in combination and in each case in pharmaceutically effective amounts (A) senna fruit dry extract and (B) plantago seeds (plantaginis ovatae semen). The composition can advantageously be manufactured by fluidized bed granulation. The composition is in particular free of guar gum, is dust-free, is dispersible in water and has a pleasant taste and can be supplemented straightforwardly with vitamins, minerals, trace elements and the like.
摘要翻译： 本发明涉及一种药物组合物，其特别适合用作泻药（泻药），其中组合物组合包含药学有效量（A）番泻奈果干提取物和（B）车前草种子（plantaginis ovatae 精液）。 组合物可以有利地通过流化床造粒制备。 该组合物特别是没有瓜尔胶，无尘，可分散在水中并具有令人愉快的味道，并可直接补充维生素，矿物质，微量元素等。
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公开(公告)号：US6143795A
公开(公告)日：2000-11-07
申请号：US299131
申请日：1999-04-26
IPC分类号： A61K9/08 , A61K31/135 , A61K31/136 , A61K31/137 , A61K47/02 , A61K47/12 , A61K47/18 , A61P31/12 , A61P35/00
CPC分类号： A61K31/137 , A61K47/183 , A61K9/0019 , A61K47/02 , A61K47/12
摘要： An aqueous solution of from about 1 mg/ml to about 5 mg/ml mitoxantrone.HCl, from about 0.01% wt. to about 0.15% wt. based on the solution of sodium edetate, sodium chloride, sodium acetate, and acetic acid, and a process for preparing the same.
摘要翻译： 约1mg / ml至约5mg / ml米托蒽醌HCl的水溶液，约0.01重量％ 至约0.15重量％。 基于依地酸钠，氯化钠，乙酸钠和乙酸的溶液及其制备方法。
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8.发明授权Salts of azelastine having improved solubility effective at treating psoriasis and providing a cytoprotective effect 有权具有改善溶解性的阿伐斯他汀盐治疗银屑病并提供细胞保护作用
公开(公告)号：US6017909A
公开(公告)日：2000-01-25
申请号：US136971
申请日：1998-08-20
申请人： Helmut Hettche , Reinhard Muckenschnabel , Gerhard Scheffler , Ilona Fleischhauer , Wolfgang Morick
发明人： Helmut Hettche , Reinhard Muckenschnabel , Gerhard Scheffler , Ilona Fleischhauer , Wolfgang Morick
CPC分类号： C07D403/04 , A61K31/55 , Y10S514/863 , Y10S514/886 , Y10S514/887
摘要： Salts of azelastine with acetic acid, gluconic acid, lactic acid or malic acid.
摘要翻译： 萘曲宁与醋酸，葡萄糖酸，乳酸或苹果酸的盐。
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9.发明授权Salts of azelastine having improved solubility useful at providing a cytoprotective effect 失效具有改善的溶解度的氮卓斯汀的盐可用于提供细胞保护作用
公开(公告)号：US5998403A
公开(公告)日：1999-12-07
申请号：US123431
申请日：1998-07-28
申请人： Helmut Hettche , Reinhard Muckenschnabel , Gerhard Scheffler , Ilona Fleischhauer , Wolfgang Morick
发明人： Helmut Hettche , Reinhard Muckenschnabel , Gerhard Scheffler , Ilona Fleischhauer , Wolfgang Morick
CPC分类号： C07D403/04 , A61K31/55 , Y10S514/863 , Y10S514/886 , Y10S514/887
摘要： The present invention relates to salts of azelastine having improved solubility in water. The salts of the present invention are prepared by reacting azelastine with acetic acid, gluconic acid, lactic acid, or malic acid. The azelastine salts are effective in providing a cytoprotective effect.
摘要翻译： 本发明涉及在水中具有改善的溶解性的氮卓斯汀盐。 本发明的盐通过使萘曲斯汀与乙酸，葡萄糖酸，乳酸或苹果酸反应来制备。 氮卓斯汀盐对提供细胞保护作用是有效的。
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