发明授权
- 专利标题： Heterocyclic compounds method of preparing them and pharmeutical compositions in which they are present
- 专利标题（中）： 制备它们的杂环化合物方法和它们存在的药物组合物
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申请号： US787910申请日： 1997-01-23
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公开(公告)号： US5859029A公开(公告)日： 1999-01-12
- 发明人: Xavier Emonds-Alt , Isabelle Grossriether , Vincenzo Proietto , Didier Van Broeck
- 申请人： Xavier Emonds-Alt , Isabelle Grossriether , Vincenzo Proietto , Didier Van Broeck
- 申请人地址： FRX Paris
- 专利权人： Sanofi
- 当前专利权人： Sanofi
- 当前专利权人地址： FRX Paris
- 优先权： FRX9501015 19950130
- 主分类号： C07D223/10
- IPC分类号： C07D223/10 ; A61K31/435 ; A61K31/4427 ; A61K31/445 ; A61K31/451 ; A61K31/55 ; A61P1/00 ; A61P1/04 ; A61P1/08 ; A61P9/00 ; A61P9/06 ; A61P9/08 ; A61P9/10 ; A61P9/12 ; A61P11/00 ; A61P13/02 ; A61P15/00 ; A61P17/00 ; A61P25/00 ; A61P25/04 ; A61P25/06 ; A61P25/08 ; A61P25/18 ; A61P25/20 ; A61P25/24 ; A61P25/26 ; A61P25/28 ; A61P25/30 ; A61P29/00 ; A61P37/00 ; A61P37/08 ; A61P43/00 ; C07D211/76 ; C07D401/06 ; C07D401/14 ; C07D453/02
摘要：
This invention relates to compounds with strong affinity for NK.sub.1 receptor and useful for preparing drugs for treating substance P-dependent pathological conditions having the formula ##STR1## in which: m is two or three;n is 0;Am is a group ##STR2## R.sub.2 is a phenyl which is unsubstituted or monosubstituted or polysubstituted by a halogen atom, a hydroxyl, a (C.sub.1 -C.sub.4)-alkoxy, a (C.sub.1 -C.sub.4)-alkyl or a trifluoromethyl, said substituents being identical or different;X is a hydrogen atom or a hydroxyl group;x is zero or one;Ar is a phenyl which is unsubstituted or monosubstituted or polysubstituted by a halogen atom; a naphthyl; or an indolyl;Z is a phenyl which is disubstituted or polysubstituted by a trifluoromethyl; and the salts thereof with mineral or organic acids and the solvates thereof.
公开/授权文献
- US4119002A Sod cutter 公开/授权日：1978-10-10
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