发明授权
US5861304A Process for the enzymatic separation of enantiomers of
rac-2-oxotricyclo�2.2.1.0 3,5! heptane-7-carboxylic acid and of
rac-2-oxotricyclo�2.2.1.0 3,5! heptane-7-carboxylic esters
失效
使用来自念珠菌的脂肪酶分离外消旋-2-氧杂环己烷-2,2.0.0,3H庚烷-7-羧酸酯的方法
- 专利标题: Process for the enzymatic separation of enantiomers of rac-2-oxotricyclo�2.2.1.0 3,5! heptane-7-carboxylic acid and of rac-2-oxotricyclo�2.2.1.0 3,5! heptane-7-carboxylic esters
- 专利标题(中): 使用来自念珠菌的脂肪酶分离外消旋-2-氧杂环己烷-2,2.0.0,3H庚烷-7-羧酸酯的方法
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申请号: US932933申请日: 1997-09-17
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公开(公告)号: US5861304A公开(公告)日: 1999-01-19
- 发明人: Wolfgang Holla , Gerhard Beck
- 申请人: Wolfgang Holla , Gerhard Beck
- 申请人地址: DEX Frankfurt am Main
- 专利权人: Hoechst Aktiengesellschaft
- 当前专利权人: Hoechst Aktiengesellschaft
- 当前专利权人地址: DEX Frankfurt am Main
- 优先权: DEX4435242.5 19941004
- 主分类号: C07C69/757
- IPC分类号: C07C69/757 ; C12P15/00 ; C12P41/00 ; C12R1/07 ; C12R1/38 ; C12R1/66 ; C12R1/72 ; C12R1/785 ; C12R1/845
摘要:
Process for the resolution of rac-2-oxotricyclo�2.2.1.0.sup.3,5 !heptane-7-carboxylic acid esters using lipase from candida.Compounds of the formula I ##STR1## in which R.sup.1 has the meanings mentioned, may be obtained in isomerically pure form from enantiomer mixtures or racemic mixtures by reacting the compound of the formula I in the presence of a lipase or esterase from porcine liver, porcine pancreas, bovine pancreas or from microorganisms such as Candida, Pseudomonas, Mucor, Rhizopus and Aspergillus, or proteases from Bacillus in the presence of water and, if desired, a cosolvent and separating from one another the esters and acids present in the solution obtained.
公开/授权文献
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