发明授权
- 专利标题： Substituted pyrrolidin-3-yl-alkyl-piperidines
- 专利标题（中）： 取代的吡咯烷-3-基 - 烷基 - 哌啶
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申请号： US795576申请日： 1997-02-06
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公开(公告)号： US5861416A公开(公告)日： 1999-01-19
- 发明人: Timothy P. Burkholder , Tieu-Binh Le , Elizabeth M. Kudlacz , George D. Maynard
- 申请人： Timothy P. Burkholder , Tieu-Binh Le , Elizabeth M. Kudlacz , George D. Maynard
- 申请人地址： OH Cincinnati
- 专利权人： Merrell Pharmaceuticals Inc.
- 当前专利权人： Merrell Pharmaceuticals Inc.
- 当前专利权人地址： OH Cincinnati
- 主分类号： C07D401/06
- IPC分类号： C07D401/06 ; C07D401/14 ; C07D409/14 ; C07D471/10 ; A61K31/445 ; C07D401/02
摘要：
The present invention relates to substituted pyrrolidinyl-3-yl-alkyl-piperidines, their stereoisomers, and pharmaceutically acceptable salts thereof and processes for preparation of the same. The compounds of the present invention are useful in their pharmacological activities such as tachykinin antagonism, especially substance P and neurokinin A antagonism, and the like. Compounds having the property of tachykinin antagonism are indicated for conditions associated with neurogenic inflammation and other diseases described herein.
公开/授权文献
- US5205984A Orthorhombic titanium niobium aluminide with vanadium 公开/授权日：1993-04-27
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