A flexible chassis for a computer system that is adapted to receive computer components of different sizes and configurations. The flexible chassis includes a printed circuit board (PCB) mounting plate that is adapted to receive baseboards of different sizes, a back panel that is adapted to receive different Input/Output (I/O) covers that accommodate the different placement of I/O plugs on different baseboards, a vertical bulkhead having a plurality of different mounting locations for a CPU fan and an I/O fan, and a relocatable PCB support rod assembly adapted to support memory and I/O cards which are coupled to different locations on the various baseboards.