发明授权
US5874578A Process for preparing guanine-containing antiviral agents and purinyl
salts useful in such process
失效
用于制备在这种方法中有用的含有鸟嘌呤的抗病毒剂和嘌呤基盐的方法
- 专利标题： Process for preparing guanine-containing antiviral agents and purinyl salts useful in such process
- 专利标题（中）： 用于制备在这种方法中有用的含有鸟嘌呤的抗病毒剂和嘌呤基盐的方法
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申请号： US7950申请日： 1993-01-25
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公开(公告)号： US5874578A公开(公告)日： 1999-02-23
- 发明人: Janak Singh , Gregory S. Bisacchi , Jollie D. Godfrey, Jr. , Toomas Mitt , Richard H. Mueller , Robert Zahler , Thomas P. Kissick
- 申请人： Janak Singh , Gregory S. Bisacchi , Jollie D. Godfrey, Jr. , Toomas Mitt , Richard H. Mueller , Robert Zahler , Thomas P. Kissick
- 申请人地址： NJ Princeton
- 专利权人： Bristol-Myers Squibb
- 当前专利权人： Bristol-Myers Squibb
- 当前专利权人地址： NJ Princeton
- 主分类号： A61K31/52
- IPC分类号： A61K31/52 ; A61P31/12 ; C07C211/63 ; C07D473/00 ; C07D473/32 ; C07D473/40 ; C07D473/18
摘要：
A purine salt of the formula ##STR1## wherein Y.sub.1 is chloro, bromo, or iodo, and R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are independently selected from alkyl and substituted alkyl is reacted with the compound of the formulaZ.sub.1 --Xto yield the purine of the formula ##STR2## wherein x is a leaving group, and Z.sub.1 is a protected form of the carbohydrate surrogate Z. Several routes are disclosed for converting this intermediate to the antiviral agent ##STR3##
公开/授权文献
- USD353974S Dish for encouraging diets 公开/授权日：1995-01-03
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