发明授权
US5876966A Compounds and methods for the stimulation and enhancement of protective
immune responses and IL-12 production
失效
用于刺激和增强保护性免疫应答和IL-12产生的化合物和方法
- 专利标题： Compounds and methods for the stimulation and enhancement of protective immune responses and IL-12 production
- 专利标题（中）： 用于刺激和增强保护性免疫应答和IL-12产生的化合物和方法
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申请号： US454036申请日： 1995-05-30
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公开(公告)号： US5876966A公开(公告)日： 1999-03-02
- 发明人: Steven G. Reed
- 申请人： Steven G. Reed
- 申请人地址： WA Seattle
- 专利权人： Corixa Corporation
- 当前专利权人： Corixa Corporation
- 当前专利权人地址： WA Seattle
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K38/00 ; A61K39/00 ; A61K39/008 ; A61K39/39 ; A61K39/395 ; A61P31/04 ; A61P33/02 ; A61P35/00 ; A61P37/04 ; C07H21/04 ; C07K14/44 ; C07K16/20 ; C12N1/21 ; C12N15/30 ; C12P21/02 ; C12P21/08 ; C12R1/19 ; A61K39/02 ; C07K1/00 ; C07H21/02
摘要：
Compounds and methods for stimulating and enhancing immune responses and for evaluating patient immune responses are disclosed. Disclosed compounds include polypeptides that contain at least a biologically active portion of a Leishmania braziliensis homolog of the eukaryotic initiation factor 4A, or a variant thereof. Such compounds are useful for stimulating a Th1 immune response and IL-12 production in patients, as well as in isolated cells and cell cultures. The polypeptides of this invention are further useful for the evaluation and treatment of patients, who may be afflicted with leishmaniasis or other disorders.
公开/授权文献
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