- 专利标题： Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
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申请号： US218861申请日： 1994-03-28
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公开(公告)号： US5879657A公开(公告)日： 1999-03-09
- 发明人: William Frank DeGrado , Shaker Ahmed Mousa , Michael Sworin , John Andrew Barrett , Scott David Edwards , Thomas David Harris , Milind Rajopadhye , Shuang Liu
- 申请人： William Frank DeGrado , Shaker Ahmed Mousa , Michael Sworin , John Andrew Barrett , Scott David Edwards , Thomas David Harris , Milind Rajopadhye , Shuang Liu
- 申请人地址： DE Wilmington
- 专利权人： The Dupont Merck Pharmaceutical Company
- 当前专利权人： The Dupont Merck Pharmaceutical Company
- 当前专利权人地址： DE Wilmington
- 主分类号： A61K38/12
- IPC分类号： A61K38/12 ; A61K49/04 ; A61K51/00 ; A61K51/04 ; A61K51/08 ; C07B59/00 ; C07D213/82 ; C07D257/00 ; C07D259/00 ; C07D277/60 ; C07D401/00 ; C07D401/12 ; C07D401/14 ; C07D413/12 ; C07K5/10 ; C07K5/103 ; C07K7/64 ; C07K14/75 ; C07K17/02 ; A61M36/14
摘要：
This invention provides novel radiopharmaceuticals that are radiolabeled cyclic compounds containing carbocyclic or heterocyclic ring systems which act as antagonists of the platelet glycoprotein IIb/IIIa complex; to methods of using said radiopharmaceuticals as imaging agents for the diagnosis of arterial and venous thrombi; to novel reagents for the preparation of said radiopharmaceuticals; and to kits comprising said reagents.
公开/授权文献
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