发明授权
- 专利标题: Amidinohydrazones as protease inhibitors
- 专利标题(中): 酰胺腙类作为蛋白酶抑制剂
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申请号: US828160申请日: 1997-03-27
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公开(公告)号: US5891909A公开(公告)日: 1999-04-06
- 发明人: Richard M. Soll , Tianbao Lu , Cynthia L. Fedde , Bruce E. Tomczuk , Carl Illig
- 申请人: Richard M. Soll , Tianbao Lu , Cynthia L. Fedde , Bruce E. Tomczuk , Carl Illig
- 申请人地址: PA Exton
- 专利权人: 3-Dimensional Pharmaceuticals, Inc.
- 当前专利权人: 3-Dimensional Pharmaceuticals, Inc.
- 当前专利权人地址: PA Exton
- 主分类号: A61K31/00
- IPC分类号: A61K31/00 ; A61K31/165 ; A61K31/18 ; A61K31/275 ; A61K31/277 ; A61K31/41 ; A61K31/415 ; A61K31/433 ; A61K31/44 ; A61K31/4406 ; A61K31/47 ; A61K31/472 ; A61P1/00 ; A61P1/18 ; A61P7/00 ; A61P7/02 ; A61P43/00 ; C07C45/29 ; C07C45/71 ; C07C47/277 ; C07C281/18 ; C07C309/67 ; C07C309/73 ; C07C309/74 ; C07C309/75 ; C07C309/77 ; C07C311/21 ; C07C323/66 ; C07D213/70 ; C07D213/71 ; C07D215/36 ; C07D217/02 ; C07D231/14 ; C07D231/18 ; C07D233/52 ; C07D285/14 ; C07D317/40 ; C07D333/34 ; A61K31/155 ; A61K31/255
摘要:
Amidino and benzamidino compounds, including compounds of the formula: ##STR1## wherein R.sup.1 -R.sup.4, R.sup.6 -R.sup.9, Y, Z, n and m are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin are described. Also described are methods for preparing the compounds of Formula I.
公开/授权文献
- US5294131A Audible arrow 公开/授权日:1994-03-15