发明授权
- 专利标题: Metalloproteinase inhibitors
- 专利标题(中): 金属蛋白酶抑制剂
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申请号: US676359申请日: 1996-07-22
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公开(公告)号: US5902791A公开(公告)日: 1999-05-11
- 发明人: Raymond Paul Beckett , Mark Whittaker , Andrew Miller
- 申请人: Raymond Paul Beckett , Mark Whittaker , Andrew Miller
- 申请人地址: GBX Oxford
- 专利权人: British Biotech Pharmaceuticals Limited
- 当前专利权人: British Biotech Pharmaceuticals Limited
- 当前专利权人地址: GBX Oxford
- 优先权: GBX9401416 19940122; GBX9413566 19940706
- 主分类号: A61K31/40
- IPC分类号: A61K31/40 ; A61K31/16 ; A61K31/165 ; A61K31/195 ; A61K31/215 ; A61K31/403 ; A61K31/4035 ; A61P1/14 ; A61P9/00 ; A61P17/00 ; A61P27/02 ; A61P29/00 ; A61P35/02 ; A61P37/00 ; A61P43/00 ; C07C237/22 ; C07C259/06 ; C07C317/50 ; C07C323/60 ; C07D209/48 ; C07C323/41
摘要:
Matrix metalloproteinase inhibiting compounds of formula (I), wherein X is a --CO.sub.2 H or --CONHOH group; and one of the groups proximate to the amide bonds is a steric bulky group, showing enhanced oral absorption. ##STR1##