发明授权
US5910568A Molecule involved in binding of sperm to egg surfaces and procedures for
use of this molecule to enhance or decrease potential fertility
失效
涉及精子与蛋表面结合的分子以及使用该分子增强或降低潜在生殖力的程序
- 专利标题： Molecule involved in binding of sperm to egg surfaces and procedures for use of this molecule to enhance or decrease potential fertility
- 专利标题（中）： 涉及精子与蛋表面结合的分子以及使用该分子增强或降低潜在生殖力的程序
-
申请号： US584671申请日： 1996-01-11
-
公开(公告)号： US5910568A公开(公告)日： 1999-06-08
- 发明人: Roy H. Hammerstedt , Palmer G. Cramer , Guy F. Barbato
- 申请人： Roy H. Hammerstedt , Palmer G. Cramer , Guy F. Barbato
- 申请人地址： PA University Park
- 专利权人： The Penn State Research Foundation
- 当前专利权人： The Penn State Research Foundation
- 当前专利权人地址： PA University Park
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; A61K38/00 ; A61P15/00 ; A61P15/08 ; C07K7/08 ; C07K14/47 ; C07K14/705 ; G01N33/53 ; C07K14/00 ; A61K38/16
摘要：
A purified polypeptide which provides for initial binding of sperm to oocyte investments and has an active amino acid sequence of SEQ ID NO:12 (Cys-Gln-Ser-Leu-Gln-Glu-Tyr-Leu-Ala-Glu-Gln-Asn-Gln-Arg-Gln-Leu-Glu-Ser-Asn -Lys-Ile-Pro-Glu-Val-Asp-Leu-Ala-Arg-Val-Val-Ala-Pro-Phe-Met-Ser-Asn-Ile-Pro-Leu-Leu-Leu-Tyr-Pro-Gln-Asp-Arg-Pro -Arg-Ser-Gln-Pro-Gln-Pro-Lys-Ala-Asn-Glu-Asp-Val-Cys); or SEQ ID NO:13 (Cys-Glu-Ser-Leu-Gln-Lys-His-Leu-Ala-Glu-Leu-Asn-His-Gln-Lys-Gln-Leu-Glu-Ser-Asn-Lys-Ile-Pro-Glu-Leu -Asp-Met-Thr-Glu-Val-Val-Ala-Pro-Phe-Met-Ala-Asn-Ile-Pro-Leu-Leu-Leu-Tyr-Pro-Gln-Asp-Gly-Pro-Arg-Ser-Lys-Pro-Gln -Pro-Lys-Asp-Asn-Gly-Asp-Val-Cys); or the shorter but biologically active SEQ ID NO:1 and SEQ ID NO:9 (Tyr-Pro-Gln-Asp-Arg-X-Arg-Ser-Gln-Pro-Gln-Pro-Lys-Ala-Asn, where X is Thr or Pro). The polypeptide is useful in improving sperm-egg binding by fresh sperm, restoring sperm-egg binding following a cryopreservation cycle, enhancing fertilizing potential, and producing antibodies to determine fertilizing potential of sperm, determining sperm-binding sites on egg investments, and contraception.
公开/授权文献
- US5061223A Homokinetic universal joint 公开/授权日：1991-10-29
信息查询
IPC分类:
