发明授权
- 专利标题： 1,4-disubstituted piperazines
- 专利标题（中）： 1,4-二取代的哌嗪
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申请号： US943726申请日： 1997-10-03
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公开(公告)号： US5916889A公开(公告)日： 1999-06-29
- 发明人: Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Knud Erik Andersen , Brett Watson , Zdenek Polivka , Otylie Konigova , Martina Kovandova , Alexandra Silhankova , Vladimir Valenta
- 申请人： Rolf Hohlweg , Peter Madsen , Tine Krogh J.o slashed.rgensen , Knud Erik Andersen , Brett Watson , Zdenek Polivka , Otylie Konigova , Martina Kovandova , Alexandra Silhankova , Vladimir Valenta
- 申请人地址： DKX Bagsvaerd
- 专利权人： Novo Nordisk A/S
- 当前专利权人： Novo Nordisk A/S
- 当前专利权人地址： DKX Bagsvaerd
- 优先权： DKX1090/96 19961004
- 主分类号： C07D295/06
- IPC分类号： C07D295/06 ; A61K31/4427 ; A61K31/4436 ; A61K31/444 ; A61K31/495 ; A61K31/496 ; A61K31/55 ; A61P3/08 ; A61P17/04 ; A61P25/06 ; A61P29/00 ; C07D213/74 ; C07D213/79 ; C07D213/80 ; C07D295/073 ; C07D295/12 ; C07D295/14 ; C07D295/155 ; C07D401/04 ; C07D401/06 ; C07D401/12 ; C07D401/14 ; C07D403/14 ; C07D405/12 ; C07D405/14 ; C07D409/12 ; C07D409/14 ; C07D413/06 ; C07D413/12 ; C07D413/14 ; C07D405/06
摘要：
The present invention relates to 1,4-disubstituted piperazines of the general formula ##STR1## wherein X, Y, Z, R.sup.1, R.sup.2 and r are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for the treatment of indications caused by or related to the secretion and circulation of insulin antagonizing peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.
公开/授权文献
- US5266204A Catalytic process 公开/授权日：1993-11-30
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