利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

65 条记录 (耗时 0.038 秒)

    Substituted homopiperidine, piperidine or pyrrolidine derivatives
    1.
    发明授权
    Substituted homopiperidine, piperidine or pyrrolidine derivatives 失效
    取代的高哌啶，哌啶或吡咯烷衍生物

    公开(公告)号：US07799924B2

    公开(公告)日：2010-09-21

    申请号：US11962455

    申请日：2007-12-21

    申请人： Jan Lindy Sorensen ,  Knud Erik Andersen ,  Ingrid Pettersson

    发明人： Jan Lindy Sorensen ,  Knud Erik Andersen ,  Ingrid Pettersson

    IPC分类号： C07D401/00 ,  A61K31/445

    CPC分类号： C07D401/04 ,  C07D413/04 ,  C07D413/06 ,  C07D413/14

    摘要： A novel class of substituted homopiperidine, piperidine and pyrrolidine derivatives, methods for their preparation, pharmaceutical compositions comprising them and use thereof in the treatment of disorders related to the histamine H3 receptor. More particularly, the compounds possess histamine H3 receptor antagonistic activity and are thus useful in the treatment of disorders in which a histamine H3 receptor blockade is beneficial.

    摘要翻译： 一类新的取代的高哌啶，哌啶和吡咯烷衍生物，其制备方法，包含它们的药物组合物及其用于治疗与组胺H3受体有关的病症的用途。 更具体地，化合物具有组胺H3受体拮抗活性，因此可用于治疗组胺H3受体阻断有益的病症。

    Heterocyclic compounds
    3.
    发明授权
    Heterocyclic compounds 失效
    杂环化合物

    公开(公告)号：US06391890B1

    公开(公告)日：2002-05-21

    申请号：US09535216

    申请日：2000-03-27

    申请人： Tine Krogh Jørgensen ,  Knud Erik Andersen ,  Rolf Hohlweg ,  Uffe Bang Olsen ,  Erik Fischer ,  Zdenek Polivka ,  Kaler Sindelar

    发明人： Tine Krogh Jørgensen ,  Knud Erik Andersen ,  Rolf Hohlweg ,  Uffe Bang Olsen ,  Erik Fischer ,  Zdenek Polivka ,  Kaler Sindelar

    IPC分类号： A61K31445

    CPC分类号： C07D295/15 ,  C07D211/70 ,  C07D409/04 ,  C07D409/14

    摘要： The present invention relates to novel N-substituted azaheterocyclic compounds of the general formula wherein X, Y, Z, R1, R2 and m are as defined in the detailed part of the present description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation, as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.

    摘要翻译： 本发明涉及X，Y，Z，R 1，R 2和m一般形式的新的N-取代的氮杂杂环化合物，如本说明书的详细部分或其盐，其制备方法，组合物 并且用于临床治疗疼痛，痛觉过敏和/或炎症性疾病，其中C-纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用，以及它们用于治疗由...引起的或与之相关的适应症 胰岛素拮抗肽的分泌和循环，例如 非胰岛素依赖性糖尿病（NIDDM）和衰老相关性肥胖。