发明授权
- 专利标题： IL-13 receptor specific chimeric proteins
- 专利标题（中）： IL-13受体特异性嵌合蛋白
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申请号： US821840申请日： 1997-03-21
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公开(公告)号： US5919456A公开(公告)日： 1999-07-06
- 发明人: Raj K. Puri , Waldemar Debinski , Ira Pastan , Nicholas Obiri
- 申请人： Raj K. Puri , Waldemar Debinski , Ira Pastan , Nicholas Obiri
- 申请人地址： DC Washington
- 专利权人： The United States of America as represented by the Secretary of the Department of Health and Human Services
- 当前专利权人： The United States of America as represented by the Secretary of the Department of Health and Human Services
- 当前专利权人地址： DC Washington
- 主分类号： C12N15/09
- IPC分类号： C12N15/09 ; A61K38/00 ; A61K39/395 ; A61K45/00 ; A61K47/48 ; A61K51/00 ; A61P35/00 ; C07K14/21 ; C07K14/54 ; C07K16/28 ; C07K19/00 ; C12N1/15 ; C12N1/19 ; C12N1/21 ; C12N5/10 ; C12N15/24
摘要：
This invention provides chimeric molecules useful for killing tumor cells bearing IL13 receptor(s) (IL-13R). The molecules comprise a cytotoxic molecule attached to a targeting molecule that specifically binds an IL-13 receptor. Preferred targeting molecules include IL-13 and anti-IL-13R antibodies.